Results 61 to 70 of about 3,675,358 (282)

Quantitative two-dimensional shadowgraphic set-up for high-sensitivity measurement of low-density laser-plasmas [PDF]

, 2006
We present a quantitative shadowgraphic method which can measure the density of a laser-generated plasma in air with sensitivity and resolution comparable or better than traditional interferometric techniques. Simultaneous comparison of both shadowgraphy
Amrutha Gopal, Borghesi, de Bruyn, Dubietis, Ghiglia, Hipp, Mao, Marcuse, Matsumoto, Michael Tatarakis, Mitchell, Stefano Minardi, Sun, Tatarakis, Trainoff, Vest   +15 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Evaluation of Cell Disruption of Chlorella Vulgaris by Pressure-Assisted Ozonation and Ultrasonication

Energies, 2016
This study evaluated the effectiveness of pressure-assisted ozonation (PAO) in Chlorella vulgaris (C. vulgaris) cell disruption, and compared the disruption result with that of the ultrasonication (US) by using four quantification indicators: cell ...
Yuanxing Huang, Shengnan Qin, Daofang Zhang, Liang Li, Yan Mu   +4 more
doaj   +1 more source

Stronger computational modelling of signalling pathways using both continuous and discrete-state methods [PDF]

, 2006
Starting from a biochemical signalling pathway model expresses in a process algebra enriched with quantitative information, we automatically derive both continuous-space and discrete-space representations suitable for numerical evaluation.
A. Aziz, A. Chatterjee, B. Schoeberl, C. Priami, D. Gillespie, D.T. Gillespie, D.T. Gillespie, F.H. Chi-Ying, J. Hillston, J. Hillston, J. Hillston, K.-H. Cho, L.F. Shampine, M. Buchholtz, M. Kwiatkowska, M. Rathinam, O. Wolkenhauer, S. Ramsey, T.E. Turner, Y. Cao   +19 more
core   +5 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Estimation of the Dynamic Contact Area From a Rolling Tire Correlated to Expert Assessment

IEEE Access, 2019
Characteristics of the tire footprint are major indicators of tire performance and provide relevant information that can be used to improve the tire design process.
Rodrigo Nava, Duc Fehr, Frank Petry, Thomas Tamisier   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain

North American Spine Society Journal
Background: Chronic low back pain is a costly condition and the leading cause of disability worldwide. A recent call to action identified the overuse of low-value health care as ineffective and potentially harmful in the context of back pain ...
Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD   +7 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Development and comparison of model‐integrated evidence approaches for bioequivalence studies with pharmacokinetic end points

CPT: Pharmacometrics & Systems Pharmacology
By applying nonlinear mixed‐effect (NLME) models, model‐integrated evidence (MIE) approaches are able to analyze bioequivalence (BE) data with pharmacokinetic end points that have sparse sampling, which is problematic for non‐compartmental analysis (NCA).
Xiaomei Chen, Henrik B. Nyberg, Mark Donnelly, Liang Zhao, Lanyan Fang, Mats O. Karlsson, Andrew C. Hooker   +6 more
doaj   +1 more source