Results 61 to 70 of about 9,095,695 (256)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Predictive Value of Post-Percutaneous Coronary Intervention Quantitative Flow Ratio for Vessel-Oriented Composite Endpoint

Journal of Interventional Cardiology, 2023
At present, there is a lack of indicators, which can accurately predict the post-percutaneous coronary intervention (post-PCI) vessel-oriented composite endpoint (VOCE).
Weibin Liu, Huaxiu Cai, Yin Zheng, Yongkang Wen, Sicheng Chen, Xiuying Xie, Huan Zeng, Hengqing Zhu, Zhonghan Ni, Fang Pei, Jun Cao, Gang Cao   +11 more
doaj   +1 more source

Impact of epicardial adipose tissue volume on hemodynamically significant coronary artery disease in Chinese patients with known or suspected coronary artery disease

Frontiers in Cardiovascular Medicine, 2023
BackgroundEpicardial adipose tissue (EAT) is directly related to coronary artery disease (CAD), but little is known about its role in hemodynamically significant CAD.
Xiangbo Jin, Beibei Gao, Jiamin Zheng, Xueer Wu, Ning Zhang, Lijun Zhu, Xinyu Zhu, Jianchang Xie, Zhen Wang, Guoxin Tong, Jinyu Huang   +10 more
doaj   +1 more source

Characterization of quantitative flow ratio and fractional flow reserve discordance using doppler flow and clinical follow-up

The International Journal of Cardiovascular Imaging, 2022
The physiological mechanisms of quantitative flow ratio and fractional flow reserve disagreement are not fully understood. We aimed to characterize the coronary flow and resistance profile of intermediate stenosed epicardial coronary arteries with concordant and discordant FFR and QFR. Post-hoc analysis of the DEFINE-FLOW study.
Westra, Jelmer; id_orcid 0000-0002-1926-0844, Eftekhari, Ashkan, Renkens, Mick, Mejía-Rentería, Hernán, Sejr-Hansen, Martin, Stegehuis, Valérie, Holm, Niels Ramsing, de Winter, Robert-Jan, Piek, Jan J, Escaned, Javier, Wykrzykowska, J. J., Christiansen, Evald Høj   +11 more
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Borderline coronary lesion assessment with quantitative flow ratio and its relation to the instantaneous wave-free ratio

Advances in Medical Sciences, 2021
Quantitative flow ratio (QFR) is a recently developed image-based index for the assessment of borderline coronary artery disease. We sought to investigate a correlation between QFR and instantaneous wave-free ratio (iFR) for the assessment of intermediate coronary stenoses.Patients with borderline coronary lesions (40-90% by visual assessment ...
Kleczyński, Paweł, Dziewierz, Artur, Rzeszutko, Łukasz, Dudek, Dariusz, Legutko, Jacek   +4 more
openaire   +4 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Clinical Significance of the Difference Between Fractional Flow Reserve and Quantitative Flow Ratio

Circulation Journal
The quantitative flow ratio (QFR), an angiography-based index for the assessment of coronary functional stenosis, correlates well with fractional flow reserve (FFR). In this study we explored the clinical significance of the difference between these values, calculated by subtracting FFR from QFR (delta QFR-FFR), in patients undergoing FFR-guided ...
Mineo, Takashi, Setoguchi, Mirei, Kanaji, Yoshihisa, Usui, Eisuke, Hada, Masahiro, Nagamine, Tatsuhiro, Ueno, Hiroki, Sayama, Kodai, Watanabe, Takahiro, Shimosato, Hikaru, Hoshino, Masahiro, Sugiyama, Tomoyo, Yonetsu, Taishi, Sasano, Tetsuo, Kakuta, Tsunekazu   +14 more
openaire   +2 more sources