Results 71 to 80 of about 7,425,705 (296)

Improvement of Sickle Cell Disease Care Mitigates the Healthcare Utilization Induced by Increased Prevalence: Experience of a Tertiary Pediatric Center

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna, Alexia Muresan, Estelle Lecluze, Karine Leduc, Nathalie Fournier, Maria Tamer, Jean‐François Delisle, Jeremi Charbonneau, Annie Viau, Jessica Darilus, Marie‐Joëlle Doré‐Bergeron, Valérie Arsenault, Evelyne Doyon‐Trottier, Stéphanie Forte, Nancy Robitaille, Yves Pastore, Thomas Pincez   +16 more
wiley   +1 more source

Identification of common genetic risk variants for autism spectrum disorder

Nature Genetics, 2019
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children.
J. Grove, S. Ripke, T. Als, M. Mattheisen, R. Walters, H. Won, Jonatan Pallesen, E. Agerbo, O. Andreassen, R. Anney, Swapnil Awashti, R. Belliveau, F. Bettella, J. Buxbaum, J. Bybjerg-Grauholm, Marie Bækvad-Hansen, Felecia Cerrato, K. Chambert, J. Christensen, C. Churchhouse, Karin Dellenvall, D. Demontis, S. Rubeis, B. Devlin, S. Djurovic, Ashley L. Dumont, J. Goldstein, C. Hansen, M. Hauberg, M. Hollegaard, S. Hope, D. Howrigan, Hailiang Huang, C. Hultman, L. Klei, J. Maller, Joanna Martin, Alicia R. Martin, J. Moran, M. Nyegaard, T. Nærland, D. Palmer, A. Palotie, C. Pedersen, M. Pedersen, Timothy dPoterba, J. Poulsen, B. S. Pourcain, P. Qvist, K. Rehnström, A. Reichenberg, J. Reichert, E. Robinson, K. Roeder, P. Roussos, E. Saemundsen, S. Sandin, F. Satterstrom, G. D. Smith, H. Stefánsson, S. Steinberg, C. Stevens, P. Sullivan, P. Turley, G. Walters, Xinyi Xu, N. Wray, M. Trzaskowski, E. Byrne, A. Abdellaoui, M. Adams, Tracy M. Air, Till F. M. Andlauer, S. Bacanu, A. Beekman, T. Bigdeli, E. Binder, D. Blackwood, J. Bryois, H. Buttenschøn, N. Cai, E. Castelao, Toni‐Kim Clarke, J. Coleman, L. Colodro-Conde, B. Couvy-Duchesne, N. Craddock, Gregory E. Crawford, G. Davies, I. Deary, F. Degenhardt, E. Derks, N. Direk, C. Dolan, E. Dunn, T. Eley, V. Escott-Price, Farnush Farhadi Hassan Kiadeh, H. Finucane, A. Forstner, J. Frank, Héléna A. Gaspar, M. Gill, F. Goes, S. Gordon, L. Hall, T. Hansen, S. Herms, I. Hickie, P. Hoffmann, G. Homuth, Carsten Horn, J. Hottenga, M. Ising, R. Jansen, E. Jorgenson, J. Knowles, I. Kohane, J. Kraft, Warren W. Kretzschmar, J. Krogh, Z. Kutalik, Yihan Li, P. Lind, D. Macintyre, D. MacKinnon, Robert M. Maier, Wolfgang Maier, J. Marchini, H. Mbarek, Patrick J. McGrath, P. McGuffin, S. Medland, D. Mehta, C. Middeldorp, E. Mihailov, Y. Milaneschi, L. Milani, Francis M. Mondimore, G. Montgomery, S. Mostafavi, N. Mullins, M. Nauck, B. Ng, M. Nivard, D. Nyholt, P. O’Reilly, H. Oskarsson, M. Owen, J. Painter, Roseann E. Peterson, E. Pettersson, W. Peyrot, G. Pistis, D. Posthuma, J. Quiroz, John P. Rice, B. Riley, M. Rivera, S. Mirza, R. Schoevers, E. Schulte, Ling Shen, Jianxin Shi, S. Shyn, E. Sigurdsson, Grant C. B. Sinnamon, J. Smit, Daniel J. Smith, F. Streit, J. Strohmaier, K. Tansey, H. Teismann, A. Teumer, Wesley Thompson, P. Thomson, T. Thorgeirsson, M. Traylor, J. Treutlein, V. Trubetskoy, A. Uitterlinden, D. Umbricht, S. Auwera, A. M. Hemert, A. Viktorin, P. Visscher, Yunpeng Wang, B. Webb, S.M. Weinsheimer, J. Wellmann, G. Willemsen, S. Witt, Yang Wu, H. Xi, Jian Yang, Futao Zhang, V. Arolt, B. Baune, K. Berger, D. Boomsma, S. Cichon, U. Dannlowski, E. D. Geus, J. DePaulo, E. Domenici, K. Domschke, T. Esko, H. Grabe, S. Hamilton, C. Hayward, A. Heath, K. Kendler, S. Kloiber, G. Lewis, Qingqin S. Li, S. Lucae, P. Madden, P. Magnusson, N. G. Martin, A. McIntosh, A. Metspalu, B. Müller-Myhsok, M. Nöthen, M. O’Donovan, S. Paciga, N. Pedersen, B. Penninx, R. Perlis, D. Porteous, J. Potash, M. Preisig, M. Rietschel, C. Schaefer, T. Schulze, J. Smoller, H. Tiemeier, R. Uher, H. Völzke, Myrna M. Weissman, C. Lewis, D. Levinson, G. Breen, M. Agee, B. Alipanahi, A. Auton, R. Bell, K. Bryc, S. Elson, P. Fontanillas, N. Furlotte, Bethann S. Hromatka, K. Huber, A. Kleinman, N. Litterman, M. McIntyre, J. Mountain, E. Noblin, C. Northover, S. Pitts, J. Sathirapongsasuti, O. V. Sazonova, J. Shelton, S. Shringarpure, J. Tung, V. Vacic, C. H. Wilson, K. Stefánsson, D. Geschwind, M. Nordentoft, D. Hougaard, T. Werge, O. Mors, P. Mortensen, B. Neale, M. Daly, A. Børglum   +275 more
semanticscholar   +1 more source

Impact of Japan's 2024 Physician Work‐Style Reform on Pediatric Hematology–Oncology: Educational Implications in a 2‐Year Survey

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Japan's 2024 physician work‐style reform introduced legally binding limits on physicians’ working hours, but its impact on education and workforce sustainability in pediatric hematology–oncology (PHO) remains unclear. Procedure We conducted a repeated cross‐sectional study with structured quantitative items and free‐text responses ...
Kiyohiko Kaizu, Masaharu Akiyama, Toshikazu Itabashi, Jun Hayakawa, Takahiro Kikuchi, Ryohei Fukunaga, Katsuyoshi Koh, Takahiro Ueda   +7 more
wiley   +1 more source

Assessment of genetic diversity in cowpea (Vigna unguiculata) [PDF]

Electronic Journal of Plant Breeding, 2010
Sixty six genotypes of cowpea (Vigna unguiculata (L.) Walp) were investigated to understand the extent of genetic diversitythrough twelve quantitative traits.
R.M.Nagalakshmi, R. Usha Kumari and M. B. Boranayaka
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Segmentation and classification of two-channel C. elegans nucleus-labeled fluorescence images

BMC Bioinformatics, 2017
Background Aging is characterized by a gradual breakdown of cellular structures. Nuclear abnormality is a hallmark of progeria in human. Analysis of age-dependent nuclear morphological changes in Caenorhabditis elegans is of great value to aging research,
Mengdi Zhao, Jie An, Haiwen Li, Jiazhi Zhang, Shang-Tong Li, Xue-Mei Li, Meng-Qiu Dong, Heng Mao, Louis Tao   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

MULTIVARIATE ANALYSIS ON PHENOTYPIC TRAITS OF BODY MEASUREMENT IN SWAMP BUFFALO ( Bubalus bubalis)

Journal of the Indonesian Tropical Animal Agriculture, 2014
The objective of this research was to study the relationship between body measurement and bodyweight and closeness among swamp buffalo at three populations in Central Java.
S. Johari, E. Kurnianto, S. Sutopo, W.A. Hamayanti   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Foveal vision reduces neural resources in agent-based game learning

Frontiers in Neuroscience
Efficient processing of information is crucial for the optimization of neural resources in both biological and artificial visual systems. In this paper, we study the efficiency that may be obtained via the use of a fovea.
Runping Chen, Gerd J. Kunde, Louis Tao, Louis Tao, Andrew T. Sornborger   +4 more
doaj   +1 more source