Results 71 to 80 of about 5,844,028 (252)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Runaway sexual selection without genetic correlations : social environments and flexible mate choice initiate and enhance the Fisher process [PDF]

, 2012
Female mating preferences are often flexible, reflecting the social environment in which they are expressed. Associated indirect genetic effects (IGEs) can affect the rate and direction of evolutionary change, but sexual selection models do not capture ...
Moore, Allen J., Bailey, Nathan William, Nathan W. Bailey, Allen J. Moore   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Segmentation and classification of two-channel C. elegans nucleus-labeled fluorescence images

BMC Bioinformatics, 2017
Background Aging is characterized by a gradual breakdown of cellular structures. Nuclear abnormality is a hallmark of progeria in human. Analysis of age-dependent nuclear morphological changes in Caenorhabditis elegans is of great value to aging research,
Mengdi Zhao, Jie An, Haiwen Li, Jiazhi Zhang, Shang-Tong Li, Xue-Mei Li, Meng-Qiu Dong, Heng Mao, Louis Tao   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Intra- and inter-individual genetic differences in gene expression [PDF]

, 2008
Genetic variation is known to influence the amount of mRNA produced by a gene. Given that the molecular machines control mRNA levels of multiple genes, we expect genetic variation in the components of these machines would influence multiple genes in a ...
Cotsapas, Chris J., Liu, M.Y., Cowley, Mark J., Nott, David J., Little, Peter F., Peter F. R. Little, Chan, E.K.F., Cotsapas, C.J., Chan, Eva K., Luo, Oscar J., Cowley, M.J., Williams, Rohan B., Eva K. F. Chan, Pulvers, Jeremy N., Michael Y. Liu, Rohan B. H. Williams, Pulvers, J.N., David J. Nott, Williams, R.B.H., Little, P.F.R., Jeremy N. Pulvers, Oscar J. Luo, Mark J. Cowley, Luo, O.J., Chris J. Cotsapas, Nott, D.J., Liu, Michael Y.   +26 more
core   +1 more source

Assessment of genetic diversity in cowpea (Vigna unguiculata) [PDF]

Electronic Journal of Plant Breeding, 2010
Sixty six genotypes of cowpea (Vigna unguiculata (L.) Walp) were investigated to understand the extent of genetic diversitythrough twelve quantitative traits.
R.M.Nagalakshmi, R. Usha Kumari and M. B. Boranayaka
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Genetic heterogeneity of residual variance in broiler chickens [PDF]

, 2006
Aims were to estimate the extent of genetic heterogeneity in environmental variance. Data comprised 99 535 records of 35-day body weights from broiler chickens reared in a controlled environment.
Rowe Suzanne J, Avendano, Santiago, Hill, William G., White, Ian M. S., White Ian MS, Ian M.S. White, Avendaño Santiago, Hill William G, Suzanne J. Rowe, William G. Hill, Suzanne J Rowe, Ian MS White, William G Hill, Santiago Avendaño, Rowe, Suzanne J.   +14 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source