Results 91 to 100 of about 1,801,438 (286)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Estimation of genetic parameters and identification of selection indices in exotic tomato genotypes [PDF]
Electronic Journal of Plant Breeding, 2014 A study was undertaken to evaluate and characterize seventeen exotic genotypes of tomato grown in eastern India and to identify important selection indices for the yield improvement of the crop.
Pemba Sherpa, N. Pandiarana, Varun Durwas Shende, Tania Seth, Subhra Mukherjee and Arup Chattopadhyay
doaj
Accurate modeling of confounding variation in eQTL studies leads to a great increase in power to detect trans-regulatory effects [PDF]
, 2011 Expression quantitative trait loci (eQTL) studies are an integral tool to investigate the genetic component of gene expression variation. A major challenge in the analysis of such studies are hidden confounding factors, such as unobserved covariates or ...
Neil Lawrence +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Resistance of Eucalyptus pellita to rust (Puccinia psidii) [PDF]
Crop Breeding and Applied Biotechnology, 2014 Eucalypts rust (Puccinia psidii) is currently one of the major diseases in commercial eucalypt plantations in Brazil. The primary method of disease control is the use of resistant genotypes, and, among the different species of Eucalyptus, E. pellita is
Marisângela Rodrigues Santos +5 more
doaj
Quantitative genetics of intraspecies hybrids [PDF]
Heredity, 1999 Quantitative genetics generally is based on the properties of the randomly fertilized (RF) population or inbred derivatives of it. Simple hybrids and hybrid swarms do not conform to this model; and only some properties of hybrid means appear to have been available.
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Genetic ResourcesThe genetic diversity of multiple animal species is now declining rapidly, highlighting the need for action to protect and preserve animal genetic resources for the long term.
Ellen-Louisa F. White +10 more
doaj +1 more source
Understanding Genetic Diversity of Sorghum Using Quantitative Traits
Scientifica, 2016 Sorghum is the important cereal crop around the world and hence understanding and utilizing the genetic variation in sorghum accessions are essential for improving the crop.
Sweta Sinha, N. Kumaravadivel
doaj +1 more source
Quantitative Genetics and Evolution
Periodicum biologorum, 2010 Today, evolution is a unifying concept in biology. A century and half ago, Darwin developed the theory of natural selection, and proposed it as the mainmechanism of evolution. A quantitative approach to the study of evolution required new theoretical developments in population and quantitative genetics. Here, I review the basic concepts of quantitative
openaire +2 more sources