Results 101 to 110 of about 2,512,472 (268)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Qualitative and Quantitative Methods to Measure Antibacterial Activity Resulting from Bacterial Competition. [PDF]

Bio Protoc, 2023
Taillefer B, Grandjean MM, Herrou J, Robert D, Mignot T, Sebban-Kreuzer C, Cascales E.   +6 more
europepmc   +1 more source

High efficiency of a double-screening method on single P-element insertion lines to identify quantitative trait mutants in Drosophila melanogaster

, 2006
Fernando Martín, Minsu Kim, Carolina Gomez‐Diaz, Bernhard T. Hovemann, Esther Alcorta   +4 more
openalex   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Bilevel DEA Model for Efficiency Evaluation and Target Setting with Stochastic Conditions

Mathematics
The effective allocation of limited resources and the establishment of targeted goals play a pivotal role in enhancing the overall efficiency of large enterprises and organizations.
Andreas C. Georgiou, Konstantinos Kaparis, Eleni-Maria Vretta, Kyriakos Bitsis, George Paltayian   +4 more
doaj   +1 more source

Using quantitative methods to understand leaf epidermal development. [PDF]

Quant Plant Biol, 2022
Kuan C, Yang SL, Ho CK.
europepmc   +1 more source

Computer vision methods for large-scale online clustering and quantitative dermatology

, 2013
Siddharth K. Madan
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Adaptive vehicle routing for humanitarian aid in conflict-affected regions: a practitioner-informed deep reinforcement learning approach

Frontiers in Future Transportation
Humanitarian aid delivery in conflict-affected regions faces significant challenges due to dynamic security risks, uncertain demand, and complex operational constraints. Traditional optimization methods struggle with computational intractability and lack
Khaled Mili, Majdi Argoubi
doaj   +1 more source

Increasing impact of quantitative methods and modeling in establishment of bioequivalence and characterization of drug delivery. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Yoon M, Babiskin A, Hu M, Wu F, Raney SG, Fang L, Zhao L.   +6 more
europepmc   +1 more source