Results 101 to 110 of about 6,348,682 (283)

Automatic facial analysis for objective assessment of facial paralysis [PDF]

, 2009
Facial Paralysis is a condition causing decreased movement on one side of the face. A quantitative, objective and reliable assessment system would be an invaluable tool for clinicians treating patients with this condition. This paper presents an approach
He, Shu, McGrenary, Stewart, O'Reilly, Brian, Soraghan, J.J.   +3 more
core  

A detailed database of sub-annual Spanish demographic statistics: 2005–2021

Scientific Data
The big data revolution has made it possible to collect, transmit and exploit huge amounts of data. The potential this offer for data analysis, however, clashes with the limitations imposed by laws on protection of personal data. This paper details a new
Josep Lledó, Jose M. Pavía
doaj   +1 more source

Enhanced Process Monitoring for the Maxwell Process via the CUSUM Control Chart and Its Application to the Carbon Fiber Industry

IEEE Access
Control charts are the diagnostic tools used in statistical applications for detecting possible changes in a process. One of the effective approaches for identifying smaller shifts in the process under the memory control charts is the cumulative sum ...
Zahid Khan, Faisal Shah, Attila I. Katona, Zsolt T. Kosztyan   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Using Quantitative Methods as Support for Audit of the Distributed Informatics Systems [PDF]

This paper highlights some issues regarding how an indicators system must be developed and used in an audit process. Distributed systems are presented from de points of view of their main properties, architectures, applications, software quality ...
Marius POPA, Sergiu Marin CAPISIZU
core  

Investigating information systems with mixed-methods research [PDF]

, 2011
Mixed-methods research, which comprises both quantitative and qualitative components, is widely perceived as a means to resolve the inherent limitations of traditional single method designs and is thus expected to yield richer and more holistic findings.
Annansingh, F., Nunes, J.M.B., Peng, G.C.   +2 more
core  

A DEMATEL–ANP-Based Evaluation of AI-Assisted Learning in Higher Education

Computers
This study proposes an indicator system for evaluating AI-assisted learning in higher education, combining evidence-based indicator development with expert-validated weighting.
Galina Ilieva, Tania Yankova, Margarita Ruseva, Stanislava Klisarova-Belcheva   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source