Results 151 to 160 of about 36,219,545 (383)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Intersectionality in quantitative research: A systematic review of its emergence and applications of theory and methods

open access: yesSSM - population health, 2021
G. Bauer   +5 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Adaptive vehicle routing for humanitarian aid in conflict-affected regions: a practitioner-informed deep reinforcement learning approach

open access: yesFrontiers in Future Transportation
Humanitarian aid delivery in conflict-affected regions faces significant challenges due to dynamic security risks, uncertain demand, and complex operational constraints. Traditional optimization methods struggle with computational intractability and lack
Khaled Mili, Majdi Argoubi
doaj   +1 more source

A METHOD FOR THE QUANTITATIVE ANALYSIS OF 17-KETOSTEROID MIXTURES

open access: hybrid, 1953
Betty L. Rubin   +2 more
openalex   +1 more source

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