Results 181 to 190 of about 6,348,682 (283)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Scoping Study into Quantitative Methods Capacity Building in Scotland [PDF]

, 2008
McVie, Susan
core  

Quantitative methods for optimizing patient outcomes in liver transplantation. [PDF]

Liver Transpl
Al-Bahou R, Bruner J, Moore H, Zarrinpar A.   +3 more
europepmc   +1 more source

The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19. [PDF]

Front Pharmacol, 2023
Xia B, Zheng L, Li Y, Sun W, Liu Y, Li L, Pang J, Chen J, Li J, Cheng H.   +9 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Assessing non-invasive quantitative methods for [¹⁸F]SynVesT-1 PET imaging of synaptic vesicle glycoprotein 2A in the rat brain. [PDF]

Eur J Nucl Med Mol Imaging
Berckmans L, Schrauwen C, Miranda A, Staelens S, Bertoglio D.   +4 more
europepmc   +1 more source

Framework for Patient Experience Value Elements in Rare Disease: A Case Study Demonstrating the Applicability of Combined Qualitative and Quantitative Methods. [PDF]

Pharmacoecon Open, 2023
McQueen RB, Mendola ND, Jakab I, Bennett J, Nair KV, Németh B, Inotai A, Kaló Z.   +7 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Roadmap to Innovation of HTA Methods (IHTAM): insights from three case studies of quantitative methods. [PDF]

Int J Technol Assess Health Care
Jiu L, Wang J, Versteeg JW, Zhang Y, Liu L, Somolinos-Simón FJ, Tapia-Galisteo J, García-Sáez G, Hogervorst MA, Li X, Mantel-Teeuwisse AK, Goettsch WG.   +11 more
europepmc   +1 more source

Quantitative methods and modeling to assess COVID-19-interrupted in vivo pharmacokinetic bioequivalence studies with two reference batches. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2022
Gong Y, Feng K, Zhang P, Lee J, Pan Y, Zhang Z, Ni Z, Bai T, Yoon M, Li B, Kim CY, Fang L, Zhao L.   +12 more
europepmc   +1 more source