Results 41 to 50 of about 2,512,472 (268)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Effectiveness of Laser Therapy in Adults with Knee Osteoarthritis: A Bivariate Meta-Analysis of Placebo-Controlled Randomized Controlled Trials

Epidemiology, Biostatistics and Public Health
Background: Knee pain represents the second most common musculoskeletal disorder after low back pain [1]. Knee osteoarthritis (OA) represents the leading cause of knee pain, as well as the most common site for OA, with a projected increase of 74.9 ...
Stefano Giuseppe Lazzarini, Donato Martella, Antonella Zambon   +2 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Complex sampling designs for the Customer Satisfaction Index estimation

Statistica, 2013
In this paper we focus on sampling designs best suited to meeting the needs of Customer Satisfaction (CS) assessment with particular attention being paid to adaptive sampling which may be useful. Complex sampling designs are illustrated in order to build
Tonio Di Battista, Pasquale Valentini
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Epidemiology of Acute Cardiovascular and Cerebrovascular Events in the Lombardy Region: A Population-Based Study (2015–2021)

Epidemiology, Biostatistics and Public Health
Introduction Cardiovascular and cerebrovascular diseases represent one of the leading causes of morbidity and mortality in Italy [1]. Acute events such as myocardial infarction and ischemic stroke have a significant clinical, economic, and social ...
Ginevra Torrigiani , Marta Baviera , Antonella Zambon   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Combining healthiness and sustainability: An analysis of consumers’ preferences and willingness to pay for functional and sustainable snack bars

Future Foods
Despite the growing attention paid by consumers and policy makers to health and sustainability issues, contribution analyzing consumers attitude towards both health related and sustainability attributes of foods are lacking.
Anna Uliano, Marcello Stanco, Giuseppe Marotta, Concetta Nazzaro   +3 more
doaj   +1 more source