Results 231 to 240 of about 19,356,818 (281)
Quantitative Structure-activity Relationship
, 2017 The book, which is related to QSAR in sciences, is divided into five main chapters. The first chapter is the Introductory chapter. The second chapter aims to provide an update of the recent advances in the field of rational design of PDE inhibitors.
openaire +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Quantitative structure-activity relationships
1979Designing of biologically active molecules on a rational basis is of utmost importance to medicinal chemists. Until about the late 1950’s most of the structure-activity correlations were emperical and qualitative. Although attempts have been made to apply quantitative methods to biological activity since last century, a major effort in this field has ...
A K, Saxena, S, Ram
openaire +2 more sources
Quantitative Structure-Activity Relationships and Carminative Activity
Journal of Pharmaceutical Sciences, 1978Carminative activities of 34 alcohols, esters, ethers, phenols, and carbonyl compounds were determined using the guinea pig isolated ileum preparation and are expressed as the ability to produce a 50% inhibition (ID50) of a standard response to carbachol. Aqueous solubilities were measured at 37 degrees using either UV absorption or GLC.
B K, Evans, K C, James, D K, Luscombe
openaire +2 more sources
Toxicity and quantitative structure-activity relationships of colchicines
Journal of Medicinal Chemistry, 1981A method for extracting LD50 values from antitumor test data is described. A quantitative structure--activity relationship (QSAR) for 7- and 10-substituted colchicines is presented. This correlation equation closely parallels that which had been derived earlier for potency. This result indicates that attempts to modify 7- and 10-substituted colchicines
F R, Quinn, Z, Neiman, J A, Beisler
openaire +2 more sources
Quantitative Structure Activity Relationships in Drug Metabolism
Current Topics in Medicinal Chemistry, 2006This review of 61 references delineates contemporary computation quantitative structure activity relationship (QSAR) approaches that have been used to elucidate the molecular features that influence the binding and metabolism of a compound by the major phase 1 and phase 2 metabolising enzymes; Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT),
Kamaldeep K, Chohan +2 more
openaire +2 more sources
Cytotoxicity of furoxans: quantitative structure-activity relationships study
Il Farmaco, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Mariana, Boiani +2 more
openaire +2 more sources
Nonparametric Regression Applied to Quantitative Structure−Activity Relationships
Journal of Chemical Information and Computer Sciences, 2000Several nonparametric regressors have been applied to modeling quantitative structure-activity relationship (QSAR) data. The simplest regressor, the Nadaraya-Watson, was assessed in a genuine multivariate setting. Other regressors, the local linear and the shifted Nadaraya-Watson, were implemented within additive models--a computationally more ...
Pere Constans, Jonathan D. Hirst
openaire +3 more sources
Sorption and Quantitative Structure-Activity Relationship (QSAR)
2014The sorption of pesticides to soils or sediments is the major factor determining their mobility, transport and bioavailability in terrestrial and aquatic environments. The organic matter is the primary sorption domain in soils or sediments and sorption is considered to be primarily a partitioning process between soil organic matter and the surrounding ...
Aleksandar Sabljic, Yoshiaki Nakagawa
openaire +1 more source
Quantitative Structure–Activity Relationships of Antimicrobial Compounds
2012A thorough antimicrobial reviewof an increasing number of reports reveals a broad spectrum of research activity in the development practices that are used to treat a variety of diseases. The quantitative relationship between chemical structure and biological activity has received considerable attention in recent years because it allows one to predict ...
Maguna, Fabiana Paola +2 more
openaire +2 more sources
Quantitative Structure-Activity Relationships of Renin Inhibitors
Mini-Reviews in Medicinal Chemistry, 2003A review is presented on quantitative structure-activity relationships (QSARs) of renin inhibitors which have potential as antihypertensive and cardiovascular agents. They inhibit the renin, an enzyme that is involved in the rate-limiting first step of the renin angiotensin system (RAS).
openaire +2 more sources