Results 251 to 260 of about 400,566 (302)

Quantitative Structure Activity Relationships in Drug Metabolism

Current Topics in Medicinal Chemistry, 2006
This review of 61 references delineates contemporary computation quantitative structure activity relationship (QSAR) approaches that have been used to elucidate the molecular features that influence the binding and metabolism of a compound by the major phase 1 and phase 2 metabolising enzymes; Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT),
Kamaldeep K, Chohan, Stuart W, Paine, Nigel J, Waters   +2 more
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Cytotoxicity of furoxans: quantitative structure-activity relationships study

Il Farmaco, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Mariana, Boiani, Hugo, Cerecetto, Mercedes, González   +2 more
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Nonparametric Regression Applied to Quantitative Structure−Activity Relationships

Journal of Chemical Information and Computer Sciences, 2000
Several nonparametric regressors have been applied to modeling quantitative structure-activity relationship (QSAR) data. The simplest regressor, the Nadaraya-Watson, was assessed in a genuine multivariate setting. Other regressors, the local linear and the shifted Nadaraya-Watson, were implemented within additive models--a computationally more ...
Pere Constans, Jonathan D. Hirst
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Quantitative Structure-Activity Relationships of Renin Inhibitors

Mini-Reviews in Medicinal Chemistry, 2003
A review is presented on quantitative structure-activity relationships (QSARs) of renin inhibitors which have potential as antihypertensive and cardiovascular agents. They inhibit the renin, an enzyme that is involved in the rate-limiting first step of the renin angiotensin system (RAS).
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Sorption and Quantitative Structure-Activity Relationship (QSAR)

2014
The sorption of pesticides to soils or sediments is the major factor determining their mobility, transport and bioavailability in terrestrial and aquatic environments. The organic matter is the primary sorption domain in soils or sediments and sorption is considered to be primarily a partitioning process between soil organic matter and the surrounding ...
Aleksandar Sabljic, Yoshiaki Nakagawa
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STERIC EFFECTS IN QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS

Pure and Applied Chemistry, 1978
Abstract
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Quantitative Structure-Activity Relationships of Antiarrhythmic Drugs

Current Pharmaceutical Design, 1998
Abstract: A Comprehensive review of quantitative structure-activity relationship (QSAR) studies on antiarrhythmic agents is presented. From the discussion point of view, the antiarrhythmic agents have been put into two broad classes: specific and nonspecific.
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Quantitative structure-activity relationships of antianginal drugs

2001
Quantitative structure-activity relationships (QSARs) of various classes of antianginal drugs, e.g. nitrates, beta-adrenergic blocking agents (beta-blockers), and calcium channel blockers (calcium antagonists), have been reviewed. This review gives an overall picture of the mode of action of each class of drugs and points out the specific ...
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Quantitative structure-activity relationships for skin permeability

Toxicology in Vitro, 1995
In vitro human skin permeability coefficient data collected by Flynn (1990) have been analysed using multiple regression analysis. An improved model for the prediction of permeability coefficients has been derived by the inclusion of the melting point as an independent variable in addition to the octanol-water partition coefficient (as logP) and ...
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Quantitative structure - activity relationships of cardiotonic agents

2000
Quantitative structure-activity relationships (QSARs) of different cardiotonic agents are presented. A critical analysis of all QSARs provides a very vivid picture of the mechanisms of varying cardiotonic agents. The cardiotonics can be broadly put into 2 categories: cardiac glycosides and nonglycoside cardiotonics, which include phosphodiesterase of ...
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