Results 31 to 40 of about 931 (212)

Automated adaptive preconditioner for quantitative susceptibility mapping [PDF]

Magnetic Resonance in Medicine, 2019
PurposeTo develop an automated adaptive preconditioner for QSM reconstruction with improved susceptibility quantification accuracy and increased image quality.Theory and MethodsThe total field was used to rapidly produce an approximate susceptibility map, which was then averaged and trended over binning to generate a spatially varying distribution ...
Zhe Liu, Yan Wen, Pascal Spincemaille, Shun Zhang, Yihao Yao, Thanh D. Nguyen, Yi Wang   +6 more
openaire   +2 more sources

Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping

Frontiers in Human Neuroscience, 2020
The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the treatment of multiple neurological and psychiatric disorders.
Jun Li, Yufei Li, Lorenzo Gutierrez, Wenying Xu, Yiwen Wu, Chunlei Liu, Chunlei Liu, Dianyou Li, Bomin Sun, Chencheng Zhang, Hongjiang Wei   +10 more
doaj   +1 more source

Biophysical contrast sources for magnetic susceptibility and R2* mapping: A combined 7 Tesla, mass spectrometry and electron paramagnetic resonance study

NeuroImage
Iron is the most abundant trace metal in the human brain and consistently shown elevated in prevalent neurological disorders. Because of its paramagnetism, brain iron can be assessed in vivo by quantitative MRI techniques such as R2* mapping and ...
Fábio Seiji Otsuka, Maria Concepción Garcia Otaduy, Roberta Diehl Rodriguez, Christian Langkammer, Jeam Haroldo Oliveira Barbosa, Carlos Ernesto Garrido Salmon   +5 more
doaj   +1 more source

Iron deposition in Parkinson’s disease by quantitative susceptibility mapping

BMC Neuroscience, 2019
Background Patients with Parkinson’s disease (PD) have elevated levels of brain iron, especially in the nigrostriatal dopaminergic system. The purpose of this study was to evaluate the iron deposition in the substantia nigra (SN) and other deep gray ...
Qiqi Chen, Yiting Chen, Yue Zhang, Furu Wang, Hongchang Yu, Caiyuan Zhang, Zhen Jiang, Weifeng Luo   +7 more
doaj   +1 more source

MRI Quantification of Liver Fibrosis Using Diamagnetic Susceptibility: An Ex Vivo Validation Study

Tomography
Background/Objectives: Liver fibrosis, if left untreated, can lead to cirrhosis and cancer. The current standard liver biopsy for fibrosis staging is invasive and prone to risks of complication.
Chao Li, Jinwei Zhang, Alexey V. Dimov, Anne K. Koehne de González, Martin R. Prince, Jiahao Li, Dominick Romano, Pascal Spincemaille, Thanh D. Nguyen, Gary M. Brittenham, Yi Wang   +10 more
doaj   +1 more source

Quantitative Susceptibility Mapping Reveals an Association between Brain Iron Load and Depression Severity

Frontiers in Human Neuroscience, 2017
Previous studies have detected abnormal serum ferritin levels in patients with depression; however, the results have been inconsistent. This study used quantitative susceptibility mapping (QSM) for the first time to examine brain iron concentration in ...
Shun Yao, Yi Zhong, Yuhao Xu, Jiasheng Qin, Ningning Zhang, Xiaolan Zhu, Yuefeng Li   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Ex-vivo quantitative susceptibility mapping of human brain hemispheres.

PLoS ONE, 2017
Ex-vivo brain quantitative susceptibility mapping (QSM) allows investigation of brain characteristics at essentially the same point in time as histopathologic examination, and therefore has the potential to become an important tool for determining the ...
Arnold M Evia, Aikaterini Kotrotsou, Ashish A Tamhane, Robert J Dawe, Alifiya Kapasi, Sue E Leurgans, Julie A Schneider, David A Bennett, Konstantinos Arfanakis   +8 more
doaj   +1 more source

The increased iron deposition of the gray matter over the whole brain in chronic migraine: An exploratory quantitative susceptibility mapping study

Molecular Pain, 2022
Background Prior studies identified iron deposition in deep brain nuclei and the periaqueductal gray matter region in chronic migraine, and less is known about the cerebral iron deposition over the whole cerebral gray matter in CM.
Zhiye Chen, He Zhao, Xiaoyan Chen, Mengqi Liu, Xin Li, Lin Ma, Shengyuan Yu   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source