Results 41 to 50 of about 72,054 (257)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Ex-vivo quantitative susceptibility mapping of human brain hemispheres.
PLoS ONE, 2017 Ex-vivo brain quantitative susceptibility mapping (QSM) allows investigation of brain characteristics at essentially the same point in time as histopathologic examination, and therefore has the potential to become an important tool for determining the ...
Arnold M Evia +8 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Frontiers in Human Neuroscience, 2017 Previous studies have detected abnormal serum ferritin levels in patients with depression; however, the results have been inconsistent. This study used quantitative susceptibility mapping (QSM) for the first time to examine brain iron concentration in ...
Shun Yao +6 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Journal of Cardiovascular Magnetic Resonance, 2019 Background Differential blood oxygenation between left (LV) and right ventricles (RV; ΔSaO2) is a key index of cardiac performance; LV dysfunction yields increased RV blood pool deoxygenation.
Yan Wen +12 more
doaj +1 more source
NeuroImage, 2020 Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image processing pipeline for quantitative susceptibility mapping (QSM) and R2* mapping of fixed post-mortem ...
Chaoyue Wang +11 more
doaj +1 more source
Molecular Pain, 2022 Background Prior studies identified iron deposition in deep brain nuclei and the periaqueductal gray matter region in chronic migraine, and less is known about the cerebral iron deposition over the whole cerebral gray matter in CM.
Zhiye Chen +6 more
doaj +1 more source
Improved Padding in CNNs for Quantitative Susceptibility Mapping
ISMRM Annual Meeting, 2023 Recently, deep learning approaches have been proposed for QSM processing - background field removal, field-to-source inversion, and single-step QSM reconstruction. In these tasks, the networks usually take local fields or total fields as inputs, which have valid voxels within volume of interests (VOIs) and invalid voxels outside of VOIs.
openaire +2 more sources
Weak‐harmonic regularization for quantitative susceptibility mapping [PDF]
Magnetic Resonance in Medicine, 2018 PurposeBackground‐field removal is a crucial preprocessing step for quantitative susceptibility mapping (QSM). Remnants from this step often contaminate the estimated local field, which in turn leads to erroneous tissue‐susceptibility reconstructions.
Carlos Milovic +5 more
openaire +4 more sources