Results 41 to 50 of about 931 (212)

Free breathing three-dimensional cardiac quantitative susceptibility mapping for differential cardiac chamber blood oxygenation – initial validation in patients with cardiovascular disease inclusive of direct comparison to invasive catheterization

Journal of Cardiovascular Magnetic Resonance, 2019
Background Differential blood oxygenation between left (LV) and right ventricles (RV; ΔSaO2) is a key index of cardiac performance; LV dysfunction yields increased RV blood pool deoxygenation.
Yan Wen, Jonathan W. Weinsaft, Thanh D. Nguyen, Zhe Liu, Evelyn M. Horn, Harsimran Singh, Jonathan Kochav, Sarah Eskreis-Winkler, Kofi Deh, Jiwon Kim, Martin R. Prince, Yi Wang, Pascal Spincemaille   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quantitative susceptibility mapping in ischemic stroke patients after successful recanalization

Scientific Reports, 2021
Quantitative susceptibility mapping (QSM) is a novel processing method for gradient-echo magnetic resonance imaging (MRI). Higher magnetic susceptibility in cortical veins have been observed on susceptibility maps in the ischemic hemisphere of stroke ...
Jasmin Probst, Marco Rohner, Malin Zahn, Marco Piccirelli, Athina Pangalu, Andreas Luft, Andreas Deistung, Jan Klohs, Susanne Wegener   +8 more
doaj   +1 more source

Quantitative susceptibility mapping as an imaging biomarker for Alzheimer’s disease: The expectations and limitations

Frontiers in Neuroscience, 2022
Alzheimer’s disease (AD) is the most common type of dementia and a distressing diagnosis for individuals and caregivers. Researchers and clinical trials have mainly focused on β-amyloid plaques, which are hypothesized to be one of the most important ...
Yuto Uchida, Yuto Uchida, Hirohito Kan, Keita Sakurai, Kenichi Oishi, Noriyuki Matsukawa   +5 more
doaj   +1 more source

Weak‐harmonic regularization for quantitative susceptibility mapping [PDF]

Magnetic Resonance in Medicine, 2018
PurposeBackground‐field removal is a crucial preprocessing step for quantitative susceptibility mapping (QSM). Remnants from this step often contaminate the estimated local field, which in turn leads to erroneous tissue‐susceptibility reconstructions.
Carlos Milovic, Berkin Bilgic, Bo Zhao, Christian Langkammer, Cristian Tejos, Julio Acosta‐Cabronero   +5 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Improved Padding in CNNs for Quantitative Susceptibility Mapping

ISMRM Annual Meeting, 2023
Recently, deep learning approaches have been proposed for QSM processing - background field removal, field-to-source inversion, and single-step QSM reconstruction. In these tasks, the networks usually take local fields or total fields as inputs, which have valid voxels within volume of interests (VOIs) and invalid voxels outside of VOIs.
openaire   +2 more sources