Results 71 to 80 of about 206,373 (329)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping [PDF]

, 2011
Quantifying tissue iron concentration in vivo is instrumental for understanding the role of iron in physiology and in neurological diseases associated with abnormal iron distribution. Herein, we use recently-developed Quantitative Susceptibility Mapping (
Adalsteinsson, Elfar, Bilgic, Berkin, Pfefferbaum, Adolf, Rohlfing, Torsten, Sullivan, Edith V.   +4 more
core   +1 more source

Improved Padding in CNNs for Quantitative Susceptibility Mapping

ISMRM Annual Meeting, 2023
Recently, deep learning approaches have been proposed for QSM processing - background field removal, field-to-source inversion, and single-step QSM reconstruction. In these tasks, the networks usually take local fields or total fields as inputs, which have valid voxels within volume of interests (VOIs) and invalid voxels outside of VOIs.
openaire   +2 more sources

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Paramagnetic Metal Accumulation in the Deep Gray Matter Nuclei Is Associated With Neurodegeneration in Wilson’s Disease

Frontiers in Neuroscience, 2020
BackgroundNeuropathological studies have revealed copper and iron accumulation in the deep gray matter (DGM) nuclei of patients with Wilson’s disease (WD).
Xiang-Zhen Yuan, Gai-Ying Li, Jia-Lin Chen, Jian-Qi Li, Xiao-Ping Wang   +4 more
doaj   +1 more source

Detailed and large-scale cost/benefit analyses of landslide prevention vs. post-event actions [PDF]

, 2015
The main aim of this paper is to test economic benefits of landslide prevention measures vs. post-event emergency actions. To this end, detailed- and large-scale analyses were performed in a training area located in the northeastern Italian pre-Alps that
Busnardo, Enrico, Floris, Mario, Genevois, R., Salbego, G., Toaldo, M.   +4 more
core   +3 more sources

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Quantitative susceptibility mapping using plug-and-play alternating direction method of multipliers

Scientific Reports, 2022
Quantitative susceptibility mapping employs regularization to reduce artifacts, yet many recent denoisers are unavailable for reconstruction. We developed a plug-and-play approach to QSM reconstruction (PnP QSM) and show its flexibility using several ...
Srikant Kamesh Iyer, Brianna F. Moon, Nicholas Josselyn, Robert M. Kurtz, Jae W. Song, Jeffrey B. Ware, S. Ali Nabavizadeh, Walter R. Witschey   +7 more
doaj   +1 more source

Intracranial Calcifications and Hemorrhages: Characterization with Quantitative Susceptibility Mapping [PDF]

Radiology, 2013
To compare gradient-echo (GRE) phase magnetic resonance (MR) imaging and quantitative susceptibility mapping (QSM) in the detection of intracranial calcifications and hemorrhages.This retrospective study was approved by the institutional review board.
Chen Weiwei, Zhu Wenzhen, Kovanlikaya IIhami, Kovanlikaya Arzu, Liu Tian, Wang Shuai, Salustri Carlo, Wang Yi   +7 more
openaire   +5 more sources

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source