Results 201 to 210 of about 96,194 (242)

From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling. [PDF]

NPJ Digit Med
Wang H, Arulraj T, Ippolito A, Popel AS.
europepmc   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Coupling quantitative systems pharmacology modelling to machine learning and artificial intelligence for drug development: its <i>pAIns</i> and <i>gAIns</i>. [PDF]

Front Syst Biol
Folguera-Blasco N, Boshier FAT, Uatay A, Pichardo-Almarza C, Lai M, Biasetti J, Dearden R, Gibbs M, Kimko H.   +8 more
europepmc   +1 more source

Eliciting the antitumor immune response with a conditionally activated PD-L1 targeting antibody analyzed with a quantitative systems pharmacology model. [PDF]

CPT Pharmacometrics Syst Pharmacol
Ippolito A, Wang H, Zhang Y, Vakil V, Bazzazi H, Popel AS.   +5 more
europepmc   +1 more source

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Quantitative Systems Pharmacology

Handbook of Experimental Pharmacology
Haya Majid, null Nidhi
exaly   +3 more sources

Quantitative systems pharmacology: a promising approach for translational pharmacology

Drug Discovery Today: Technologies, 2016
Biopharmaceutical companies have increasingly been exploring Quantitative Systems Pharmacology (QSP) as a potential avenue to address current challenges in drug development. In this paper, we discuss the application of QSP modeling approaches to address challenges in the translational of preclinical findings to the clinic, a high risk area of drug ...
K, Gadkar, D, Kirouac, N, Parrott, S, Ramanujan   +3 more
openaire   +2 more sources