Results 211 to 220 of about 267,706 (322)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Integrating Pharmacokinetics and Quantitative Systems Pharmacology Approaches in Generative Drug Design. [PDF]

J Chem Inf Model
van den Maagdenberg HW, de Mol van Otterloo J, van Hasselt JGC, van der Graaf PH, van Westen GJP.   +4 more
europepmc   +1 more source

A PK-Driven Quantitative Systems Pharmacology Model Predicts Cytokine Release Syndrome Severity Across T Cell-Activating Therapies via a Locked Cytokine Amplification Network

Hajar Besbassi
openalex   +1 more source

Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington’s Disease Model through the Application of Quantitative Systems Pharmacology [PDF]

, 2017
Fen Pei, Hongchun Li, Mark J. Henderson, Steven A. Titus, Ajit Jadhav, Anton Simeonov, Murat Can Çobanoğlu, Seyed H. Mousavi, Tongying Shun, Lee McDermott, Prema Iyer, Michael Fioravanti, Diane L. Carlisle, Robert M. Friedlander, İvet Bahar, D. Lansing Taylor, Timothy R. Lezon, Andrew M. Stern, Mark E. Schurdak   +18 more
openalex   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura. [PDF]

CPT Pharmacometrics Syst Pharmacol
McBride C, Jiang J, Zhang Z, Tolsma J, Patwari P, Mellgård B, Vakilynejad M, Bhattacharya I, Zhu AZX.   +8 more
europepmc   +1 more source

Deriving mechanism-based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Falkenhagen U, Knöchel J, Kloft C, Huisinga W.   +3 more
europepmc   +1 more source

An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias [PDF]

, 2019
Jennifer L. Wilson, Dan Lü, Nick Corr, Aaron Fullerton, James Lu   +4 more
openalex   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

A quantitative systems pharmacology approach to support mRNA vaccine development and optimization

CPT: Pharmacometrics & Systems Pharmacology, 2021
Gianluca Selvaggio, Lorena Leonardelli, Giuseppe Lofano, Stephanie Fresnay, Silvia Parolo, Duccio Medini, Emilio Siena, Luca Marchetti   +7 more
doaj   +1 more source