Results 281 to 290 of about 267,706 (322)

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Eliciting the antitumor immune response with a conditionally activated PD-L1 targeting antibody analyzed with a quantitative systems pharmacology model. [PDF]

CPT Pharmacometrics Syst Pharmacol
Ippolito A, Wang H, Zhang Y, Vakil V, Bazzazi H, Popel AS.   +5 more
europepmc   +1 more source

Integrating Motor Function Scores of Spinal Muscular Atrophy in a Quantitative Systems Pharmacology Model of Neurofilament

Alessio Paris, Pranami Bora, Silvia Parolo, Michael Monine, Nick van der Munnik, Stephanie Fradette, Enrico Domenici, Ivan Nestorov, Luca Marchetti   +8 more
openalex   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Quantitative Systems Pharmacology Modeling of X-linked Hypophosphatemia Disease Pathway Normalization to Predict the Impact of Burosumab Treatment on Serum Biomarkers in Adult and Pediatric Patients

Daisuke Takaichi, Andy Gewitz, Hiroki Okada, Krina Mehta, Jun Hosogi, Yoshinori Nagata, Kiersten Utsey, Matthew Riggs   +7 more
openalex   +1 more source

Real-World Application of a Quantitative Systems Pharmacology (QSP) Model to Predict Potassium Concentrations from Electronic Health Records: A Pilot Case towards Prescribing Monitoring of Spironolactone. [PDF]

Pharmaceuticals (Basel)
Meid AD, Scherkl C, Metzner M, Czock D, Seidling HM.   +4 more
europepmc   +1 more source

Leveraging quantitative systems pharmacology (QSP) modeling to understand effects of corticosteroids on immune cells and cytokine release following administration of SC Epcoritamab

Nasrin Afzal, Tommy Li, Mathew Putnins, Kinjal Sanghavi, Monica Wielgos-Bonvallet, Christian Winther Eskelund, A. Steele, Mariana Sacchi, Manish Gupta, Steven Xu, Craig J. Thalhauser   +10 more
openalex   +1 more source

Development of a Quantitative Systems Pharmacology (QSP) Model of the Complement System Capturing Crosstalk Between the Classical and Alternative Pathways

Samira Anbari Meybodi, Shep Smithline, Craig Thalhauser, Fulya Akpinar Singh   +3 more
openalex   +1 more source

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Quantitative Systems Pharmacology

Handbook of Experimental Pharmacology
Haya Majid, null Nidhi
exaly   +3 more sources