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, 2012 Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes ...
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Analysis of Quantitative Trait Loci
2016Although the term quantitative trait locus (QTL) strictly refers merely to a genetic variant that causes changes in a quantitative phenotype such as height, QTL analysis more usually describes techniques used to study oligogenic or polygenic traits where each identified locus contributes a relatively small amount to the genetic determination of the ...
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Mapping Multiple Quantitative Trait Loci for Ordinal Traits
Behavior Genetics, 2004Many complex traits in humans and other organisms show ordinal phenotypic variation but do not follow a simple Mendelian pattern of inheritance. These ordinal traits are presumably determined by many factors, including genetic and environmental components. Several statistical approaches to mapping quantitative trait loci (QTL) for such traits have been
Nengjun, Yi +3 more
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Analysis of Quantitative Trait Loci
2008Diseases with complex inheritance are characterized by multiple genetic and environmental factors that often interact to produce clinical symptoms. In addition, etiological heterogeneity (different risk factors causing similar phenotypes) obscure the inheritance pattern among affected relatives and hamper the feasibility of gene-mapping studies.
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Mapping quantitative trait loci for traits defined as ratios
Genetica, 2007Many traits are defined as ratios of two quantitative traits. Methods of QTL mapping for regular quantitative traits are not optimal when applied to ratios due to lack of normality for traits defined as ratios. We develop a new method of QTL mapping for traits defined as ratios.
Runqing, Yang, Jiahan, Li, Shizhong, Xu
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1995
The preceding chapters demonstrate the utility of behavior genetic methodology and the twin/family study design for determining etiological components of traits of medical and behavioral importance. Knowledge of the relative influence of genetic and environmental determinants, their developmental patterns, their different manifestations in males and ...
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The preceding chapters demonstrate the utility of behavior genetic methodology and the twin/family study design for determining etiological components of traits of medical and behavioral importance. Knowledge of the relative influence of genetic and environmental determinants, their developmental patterns, their different manifestations in males and ...
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Quantitative Trait Loci (QTL) Mapping
2019Quantitative trait loci (QTL) are genetic regions that influence phenotypic variation of a complex trait, often through genetic interactions with each other and the environment. These are commonly identified through a statistical genetic analysis known as QTL mapping. Here, I present a step-by-step, practical approach to QTL mapping along with a sample
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Mapping of Quantitative Trait Loci
2015The genomic region associated with the expression of a quantitative trait is referred to as quantitative trait locus (QTL), which may contain one or more genes. QTLs have been grouped into different categories on the basis of their effect size, the effect of environment on their expression, and the manner of their action. QTL mapping is generally based
B. D. Singh, A. K. Singh
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Interaction and quantitative trait loci
Australian Journal of Experimental Agriculture, 2004Parallel searches for quantitative trait loci (QTL) for growth-related traits in different populations frequently detect sets of QTL that hardly overlap. Thus, many QTL potentially exist. Tools for the detection of QTL that interact are available and are currently being tested. Initial results suggest that epistasis is widespread.
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Molecular quantitative trait loci
Nature Reviews Methods Primers, 2023François Aguet +6 more
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