Results 61 to 70 of about 308,676 (247)

Identification of potential therapeutic targets for problematic alcohol use using multi-omics dataResearch in context

EBioMedicine
Summary: Background: Problematic alcohol use (PAU) is a serious global health issue with limited treatment options. Although genetic studies have identified genomic regions associated with PAU, the specific causal genes and proteins remain unclear. This
Dong June Lee, Minku Song, Soohyun Lim, Sanghyeon Park, Hyejin Kim, Yeeun Ahn, Faith Choi, Woojae Myung, Hong-Hee Won   +8 more
doaj   +1 more source

Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci

Molecular Autism, 2012
Background Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common variants with autism susceptibility risk
Davis Lea K, Gamazon Eric R, Kistner-Griffin Emily, Badner Judith A, Liu Chunyu, Cook Edwin H, Sutcliffe James S, Cox Nancy J   +7 more
doaj   +1 more source

A Novel Targeted Learning Method for Quantitative Trait Loci Mapping [PDF]

, 2014
We present a novel semiparametric method for quantitative trait loci (QTL) mapping in experimental crosses. Conventional genetic mapping methods typically assume parametric models with Gaussian errors and obtain parameter estimates through maximum ...
Gruber, Rose, Stitelman, Tibshirani, van der Laan   +4 more
core   +2 more sources

Rice and cold stress: methods for its evaluation and summary of cold tolerance-related quantitative trait loci

Rice, 2014
Cold stress adversely affects rice (Oryza sativa L.) growth and productivity, and has so far determined its geographical distribution. Dissecting cold stress-mediated physiological changes and understanding their genetic causes will facilitate the ...
Qi Zhang, Qiuhong Chen, Shaoling Wang, Yahui Hong, Zhilong Wang   +4 more
semanticscholar   +1 more source

Quantitative trait loci for bone traits segregating independently of those for growth in an F-2 broiler X layer cross [PDF]

, 2007
An F broiler-layer cross was phenotyped for 18 skeletal traits at 6, 7 and 9 weeks of age and genotyped with 120 microsatellite markers. Interval mapping identified 61 suggestive and significant QTL on 16 of the 25 linkage groups for 16 traits.
A.S. Law, Bradshaw RH, D.R. Morrice, D.W. Burt, de Koning DJ, de Koning DJ, Duff SRI, Haley CS, Hiney KM, Hocking PM, Hocking PM, Ikeobi CON, Ikeobi CON, Jansen R, Knott SA, Law AS, Manichaikul A, Moore T, Navarro P, Nicholson D, P.M. Hocking, P.W.A. Sharman, Sasaki O, Schreiweis MA, Seaton G, Sewalem A, Smith C, Williams B, Wong GKS, Zeng Z-B   +29 more
core   +1 more source

Construction of a high-density genetic map using specific-locus amplified fragment sequencing and quantitative trait loci analysis for tillering related traits in Psathyrostachys juncea perennial grass [PDF]

PeerJ
Background Russian wildrye (RWR, Psathyrostachys juncea) is an outcrossing perennial grass that plays a crucial role in foragaing and rangeland restoration due to its tiller producing capabilities, nevertheless, a genetic map has yet to be constructed ...
Yingmei Ma, Yudong Chang, Zhen Li, Zhiqi Gao, Feng Han, Yong Wang, Lan Yun   +6 more
doaj   +2 more sources

Fourteen years of R/qtl: Just barely sustainable

, 2014
R/qtl is an R package for mapping quantitative trait loci (genetic loci that contribute to variation in quantitative traits) in experimental crosses. Its development began in 2000. There have been 38 software releases since 2001.
Broman, Karl W.
core   +2 more sources

Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type

BMC Genomics, 2014
Individual genotypes at specific loci can result in different patterns of DNA methylation. These methylation quantitative trait loci (meQTLs) influence methylation across extended genomic regions and may underlie direct SNP associations or gene ...
Alicia K. Smith, V. Kilaru, M. Koçak, L. Almli, Kristina B. Mercer, K. Ressler, F. Tylavsky, K. Conneely   +7 more
semanticscholar   +1 more source

Identification of Gene Variants Associated with Melanocyte Stem Cell Differentiation in Mice Predisposed for Hair Graying

G3: Genes, Genomes, Genetics, 2019
Age-related hair graying is caused by malfunction in the regenerative potential of the adult pigmentation system. The retention of hair color over the life of an organism is dependent on the ability of the melanocyte stem cells and their progeny to ...
Allison C. Fialkowski, Denise J. Levy, Dawn E. Watkins-Chow, Joseph W. Palmer, Roshan Darji, Hemant K. Tiwari, William J. Pavan, Melissa L. Harris   +7 more
doaj   +1 more source

Identification of Quantitative Trait Loci Determining Vegetative Growth Traits in Coffea Canephor [PDF]

, 2011
Recently the use of molecular markers has been successfully applied for some crops. For coffee, new opportunities have been opened since Nestlé R&D Centre in collaboration with ICCRI completed the first genetic map of Coffea canephora. This study was
Crouzillat, C. (Crouzillat), Priyono, P. (Priyono), Sumirat, U. (Ucu)   +2 more
core