Results 91 to 100 of about 123,625 (288)

A genetic risk score based on BCL11A and HBS1L‐MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients

British Journal of Haematology, EarlyView.
Summary Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co‐inheritance of genetic variants that regulate globin expression.
Gabriela S. Arcanjo, Alexsandro P. Silva, Madi V. Diniz, Igor F. Domingos, Diego A. Pereira‐Martins, Amanda B. Araújo, Talita S. S. França, Ana C. Anjos, Aderson S. Araujo, Edis Belini‐Junior, Sara T. O. Saad, Fernando F. Costa, Antonio R. Lucena‐Araujo, Marcos André C. Bezerra   +13 more
wiley   +1 more source

Use of Cluster Analysis for Identifying Metafounders

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT In the metafounder approach, the relationship matrix of metafounders, Γ$$ \boldsymbol{\Gamma} $$ is used to transfer information on relationships between pedigree founders into the numerator relationship matrix A$$ \mathbf{A} $$, creating matrix AΓ$$ {\mathbf{A}}^{\boldsymbol{\Gamma}} $$.
Christine Anglhuber, Christian Edel, Eduardo C. G. Pimentel, Reiner Emmerling, Kay‐Uwe Götz, Georg Thaller   +5 more
wiley   +1 more source

Unravelling the Genetic Mechanisms of Litter Traits in a Maternal Line of Pigs

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Reproductive traits related to litter size are the main indicators of reproductive efficiency in pig production and are continuously evaluated for the selection of maternal lines. Several environmental and genetic factors are involved with the development of these traits.
Guilherme Oselame, Suelen Fernandes Padilha, Maurício Egídio Cantão, Jane de Oliveira Peixoto, Aline Zampar, Adriana Mércia Guaratini Ibelli, Luis Orlando Duitama Carreño, Jader Silva Lopes, Pedro Henrique Ferreira Freitas, Marcelo Silva Freitas, Mônica Corrêa Ledur   +10 more
wiley   +1 more source

Massively parallel reporter assay confirms regulatory potential of hQTLs and reveals important variants in lupus and other autoimmune diseases

HGG Advances
Summary: We designed a massively parallel reporter assay (MPRA) in an Epstein-Barr virus transformed B cell line to directly characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs ...
Yao Fu, Jennifer A. Kelly, Jaanam Gopalakrishnan, Richard C. Pelikan, Kandice L. Tessneer, Satish Pasula, Kiely Grundahl, David A. Murphy, Patrick M. Gaffney   +8 more
doaj   +1 more source

Genome-Wide Association Studies for Pasmo Resistance in Flax (Linum usitatissimum L.)

Frontiers in Plant Science, 2019
Pasmo is one of the most widespread diseases threatening flax production. To identify genetic regions associated with pasmo resistance (PR), a genome-wide association study was performed on 370 accessions from the flax core collection.
Liqiang He, Liqiang He, Jin Xiao, Khalid Y. Rashid, Zhen Yao, Pingchuan Li, Gaofeng Jia, Xiue Wang, Sylvie Cloutier, Frank M. You, Frank M. You   +10 more
doaj   +1 more source

Genetic Parameters and Genome‐Wide Association Studies for Fertility and Reproduction Traits in U.S. Katahdin Sheep Based on the Single‐Step GBLUP Methodology

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT Sheep production contributes to a secure and diverse food and fibre supply in the United States, with growing ethnic diversity strengthening demand. Katahdin is a composite hair‐type sheep breed developed in the United States that has become the most popular breed in many regions of the country and the first one to have genomic selection ...
Alejandra Toro Ospina, Ronald M. Lewis, Bradley A. Freking, Joan M. Burke, Thomas W. Murphy, Carrie S. Wilson, Luiz F. Brito   +6 more
wiley   +1 more source

Epistatic QTL pairs associated with meat quality and carcass composition traits in a porcine Duroc × Pietrain population

Genetics Selection Evolution, 2010
Background Quantitative trait loci (QTL) analyses in pig have revealed numerous individual QTL affecting growth, carcass composition, reproduction and meat quality, indicating a complex genetic architecture.
Jüngst Heinz, Tesfaye Dawit, Phatsara Chirawath, Buschbell Heiko, Jonas Elisabeth, Große-Brinkhaus Christine, Looft Christian, Schellander Karl, Tholen Ernst   +8 more
doaj   +1 more source

Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines [PDF]

, 2018
AR056280 awarded to DAB and AL. AIHC supported by IMS and Elphinstone Scholarship from the University of Aberdeen.
Blizard, David A, Carbonetto, Peter, Gregory, Jennifer S, Gyekis, Joseph P, Hernandez Cordero, Ana I, Lionikas, Arimantas, Vandenbergh, David J, Verri, Gioia Riboni   +7 more
core   +1 more source

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, EarlyView.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source

QTL mapping to anthracnose leaf blight resistance in tropical maize

Crop Breeding and Applied Biotechnology, 2017
The objectives were to map genomic regions associated with quantitative trait loci (QTL) to anthracnose leaf blight (ALB) in tropical maize, and to determine the effects of the loci on resistance to the pathogenic fungus Colletotrichum graminicola (Ces.).
Rodrigo Rodrigues Matiello, Cristiane Romanek, Caroline de Jesus Coelho, Lilian Schafascheck, Danilo Fernando Guimarães Silva, José Raulindo Gardingo   +5 more
doaj