Results 71 to 80 of about 361,741 (406)
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
A general approximation for the dynamics of quantitative traits [PDF]
, 2015 Selection, mutation and random drift affect the dynamics of allele frequencies and consequently of quantitative traits. While the macroscopic dynamics of quantitative traits can be measured, the underlying allele frequencies are typically unobserved. Can we understand how the macroscopic observables evolve without following these microscopic processes?
arxiv +1 more source
eQTL Studies: from Bulk Tissues to Single Cells [PDF]
arXiv, 2023 An expression quantitative trait locus (eQTL) is a chromosomal region where genetic variants are associated with the expression levels of certain genes that can be both nearby or distant. The identifications of eQTLs for different tissues, cell types, and contexts have led to better understanding of the dynamic regulations of gene expressions and ...
arxiv
Threshold and power for Quantitative Trait Locus detection [PDF]
, 2010 We propose several new methods to calculate threshold and power for Quantitative Trait Locus (QTL) detection. They are based on asymptotic theoretical results presented in Rabier et al. (2009) . The asymptotic validity is checked by simulations.
Azaïs, Jean-Marc +3 more
core +1 more source
Multiple locus linkage analysis of genomewide expression in yeast. [PDF]
, 2005 With the ability to measure thousands of related phenotypes from a single biological sample, it is now feasible to genetically dissect systems-level biological phenomena.
Akey, Joshua M +2 more
core +4 more sources
Journal of Experimental Botany, 2016 Highlight We identified different expression levels of FT5a, an ortholog of FLOWERING LOCUS T, as the molecular basis of a quantitative trait locus that promotes flowering under long-day conditions in soybean.
R. Takeshima +14 more
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
Linkage disequilibrium fine mapping of quantitative trait loci: A simulation study
Genetics Selection Evolution, 2003 Recently, the use of linkage disequilibrium (LD) to locate genes which affect quantitative traits (QTL) has received an increasing interest, but the plausibility of fine mapping using linkage disequilibrium techniques for QTL has not been well studied ...
Pérez-Enciso Miguel +3 more
doaj +1 more source
Advanced Biology, EarlyView.The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez +8 more
wiley +1 more source
Quantitative trait locus mapping of soybean maturity gene E5
Breeding Science, 2016 Time to flowering and maturity in soybean is controlled by loci E1 to E5, and E7 to E9. These loci were assigned to molecular linkage groups (MLGs) except for E5. This study was conducted to map the E5 locus using F2 populations expected to segregate for
A. Dissanayaka +7 more
semanticscholar +1 more source