Results 81 to 90 of about 141,382 (327)

A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer

Advanced Science, EarlyView.
The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang, Matthew C. Hill, Mingxing He, Junhao Chen, Zirui Wang, Patrick T. Ellinor, Min Li   +6 more
wiley   +1 more source

Accurate Estimation of Quantitative Trait Locus Effects with Epistatic by Improved Variational Linear Regression [PDF]

arXiv, 2015
Bayesian approaches to variable selection have been widely used for quantitative trait locus (QTL) mapping. The Markov chain Monte Carlo (MCMC) algorithms for that aim are often difficult to be implemented for high-dimensional variable selection problems, such as the ones arising in epistatic analysis.
arxiv  

A quantitative trait locus for nictation behavior on chromosome V

microPublication biology, 2017
Lee et al., 2017 showed that CB4856 has a lower nictation ratio (the number of nictating dauers over the number of moving dauers on a micro-dirt chip) than N2, and that a genetic locus (nict-1) on chromosome IV mediates this phenotype difference. Although this paper had no evidence of any other genetic loci for nictation behavior, we have studied other
Daehan Lee, Jun Kim, Junho Lee
openaire   +3 more sources

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Gene by environment QTL mapping through multiple trait analyses in blood pressure salt-sensitivity: identification of a novel QTL in rat chromosome 5

BMC Medical Genetics, 2006
Background The genetic mechanisms underlying interindividual blood pressure variation reflect the complex interplay of both genetic and environmental variables.
Tôrres César H, Pereira Alexandre C, Soler Júlia, Krieger José E   +3 more
doaj   +1 more source

Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives

Advanced Science, EarlyView.
This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao, Xi Cui, Shenglong Ding, Ketao Wang, Mingzhu Zhang   +4 more
wiley   +1 more source

Functional traits of riparian trees in the lower Fitzroy River, Western Australia

Ecohydrology, Volume 16, Issue 1, January 2023., 2023
Abstract Riparian trees are critically important for maintaining the ecological function of freshwater ecosystems. Globally, anthropogenic changes to water regimes are impacting the health and distribution of riparian trees. Understanding the physiological constraints on the distribution of riparian tree species in relation to the water regime is ...
Caroline A. Canham, Calum Woods, Samantha A. Setterfield, Erik J. Veneklaas, Fiona L. Freestone, Leah S. Beesley, Michael M. Douglas   +6 more
wiley   +1 more source

Evolution of assortative mating in a population expressing dominance.

PLoS ONE, 2011
In this article, we study the influence of dominance on the evolution of assortative mating. We perform a population-genetic analysis of a two-locus two-allele model.
Kristan A Schneider, Stephan Peischl
doaj   +1 more source

Successful Hunt for Quantitative Trait Locus in Thrombophilia [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
In recent years, our knowledge of the genetic mechanisms of thrombophilia has advanced considerably. The elucidation of the protein C system with the identification of protein C and protein S deficiencies and activated protein C (APC) resistance due to a factor V gene mutation (FV Leiden) as major risk factors of thrombosis has been instrumental for ...
openaire   +2 more sources