Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene[S]
Journal of Lipid Research, 2009 To identify genes controlling plasma HDL and triglyceride levels, quantitative trait locus (QTL) analysis was performed in one backcross, (NZO/H1Lt × NON/LtJ) × NON/LtJ, and three intercrosses, C57BL/6J × DBA/2J, C57BL/6J × C3H/HeJ, and NZB/B1NJ × NZW ...
Zhiguang Su +6 more
doaj +1 more source
A multi‐trait multi‐locus stepwise approach for conducting GWAS on correlated traits
The Plant Genome, 2022 The ability to accurately quantify the simultaneous effect of multiple genomic loci on multiple traits is now possible due to current and emerging high‐throughput genotyping and phenotyping technologies.
Samuel B. Fernandes +3 more
doaj +1 more source
Additive Genetic Variation under Intraspecific Competition and Stabilizing Selection: A Two-Locus Study [Revised June 2002] [PDF]
, 2002 A diallelic two-locus model is investigated in which the loci determine the genotypic value of a quantitative trait additively. Fitness has two components: stabilizing selection on the trait and a frequency-dependent component, as induced for instance if
Buerger, R.
core
Near-periodic substitution and the genetic variance induced by environmental change [PDF]
, 2006 We investigate a model that describes the evolution of a diploid sexual population in a changing environment. Individuals have discrete generations and are subject to selection on the phenotypic value of a quantitative trait, which is controlled by a ...
Barton +29 more
core +3 more sources
Rank-Based Statistical Methodologies for Quantitative Trait Locus Mapping [PDF]
Genetics, 2003 Abstract This article addresses the identification of genetic loci (QTL and elsewhere) that influence nonnormal quantitative traits with focus on experimental crosses. QTL mapping is typically based on the assumption that the traits follow normal distributions, which may not be true in practice.
Fei, Zou +2 more
openaire +2 more sources
Fast empirical Bayesian LASSO for multiple quantitative trait locus mapping
BMC Bioinformatics, 2011 Background The Bayesian shrinkage technique has been applied to multiple quantitative trait loci (QTLs) mapping to estimate the genetic effects of QTLs on quantitative traits from a very large set of possible effects including the main and epistatic ...
Xu Shizhong, Huang Anhui, Cai Xiaodong
doaj +1 more source
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans [PDF]
, 2017 Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions ...
Allbutt TC +34 more
core +1 more source
Genetic variants associated with the root system architecture of oilseed rape (Brassica napus L.) under contrasting phosphate supply [PDF]
, 2017 Breeding crops with ideal root system architecture for efficient absorption of phosphorus is an important strategy to reduce the use of phosphate fertilizers.
Broadley, Martin R. +12 more
core +1 more source
Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
Human Molecular Genetics, 2015 Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints resulting from the age-associated loss of cartilage. Well-powered genetic studies have identified a number of DNA polymorphisms that are associated with OA ...
M. Rushton +9 more
semanticscholar +1 more source
Semiparametric Quantitative-Trait-Locus Mapping: II. on Censored Age-at-Onset [PDF]
, 2004 In genetic studies, the variation in genotypes may not only affect different inheritance patterns in qualitative traits, but may also affect the age-at-onset as quantitative trait.
Chen, Ying Qing +2 more
core +1 more source