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Quantitative Traits and Quantitative Genetics
2014In contrast with qualitative or dichotomous traits, quantitative traits are measured using quantitative or semi-quantitative variables and their inheritance is controlled by multiple genes acting independently or in association. Quantitative traits are also influenced to varying degrees by the environment and this explains why they are often designated
Jean-Louis Guénet +3 more
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Association and linkage with quantitative traits
Genetic Epidemiology, 1995AbstractThis paper examines two approaches for the analysis of quantitative traits: (1) association studies and (2) linkage studies. The trait studied was Q1 from simulated Problem 2 data set in Genetic Analysis Workshop 9. Our purpose was to evaluate associations present in the data, to identify nongenetic and genetic predictors of the trait, and to ...
T M, King, D, Zhu, C I, Amos
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Quantitative trait loci and psychopharmacology
Journal of Psychopharmacology, 1991Unlike simple Mendelian characteristics, individual differences in behavior, including behavioral responses to drugs, are generally distributed continuously, show substantial non-genetic as well as genetic influence, and appear to be influenced by many genes rather than one or two major genes.
Plomin, R, McClearn, G E, Gora-Maslak, G
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Analysis of Quantitative Trait Loci
2016Although the term quantitative trait locus (QTL) strictly refers merely to a genetic variant that causes changes in a quantitative phenotype such as height, QTL analysis more usually describes techniques used to study oligogenic or polygenic traits where each identified locus contributes a relatively small amount to the genetic determination of the ...
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Multipoint analysis of quantitative traits
Genetic Epidemiology, 1997Complete multipoint analysis as implemented by MAPMAKER/SIBS was used to identify the chromosomal regions with the strongest evidence of linkage. Three different quantitative sib-pair methods were compared. For each trait the maximum lod/Z score was used to implicate a chromosomal region.
Marlow, A J, John, S, Worthington, J
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Parameters of Quantitative Trait Loci
Critical Reviews™ in Eukaryotic Gene Expression, 2007Most traits of medical relevance follow quantitative inheritance patterns. The genetic dissection of quantitative traits poses special challenges for geneticists mainly because of low penetrance and gene-gene and gene-environment interactions. Emerging genome resources and technologies are enabling systematic investigation of the genetic architecture ...
Jian, Yan, Weikuan, Gu
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Quantitative Trait Loci Mapping
2008This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping.
Dong-Hai, Xiong +9 more
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COMPARATIVE MAPPING OF QUANTITATIVE TRAITS IN GRAPE
Acta Horticulturae, 2005The development of DNA sequences and the increasing number of mapping projects are exploiting the potential of co-dominant molecular markers to generate a common reference genetic map for grape. A set of microsatellite markers enables the identification of all 19 homologous linkage groups (2n = 38 for Euvitis) and the direct comparison of information ...
Costantini, Laura +3 more
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The Evolution of Quantitative Traits
2022Several species of grasses have been modified by human selection to make them the major food in many parts of the world. Among them is rice (Oryza sativa), seen here in beautiful terraces in Vietnam.
Douglas J. Futuyma, Mark Kirkpatrick
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Quantitative trait loci in Drosophila
Nature Reviews Genetics, 2001Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been
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