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Quantitative trait linkage studies of diabetes-related traits
Current Diabetes Reports, 2003Genetic linkage methods for diseases with complex inheritance are based on assessment of allele sharing between affected relative pairs, but such methods have low power to detect genes with moderate effects. This may explain the difficulty in replication for many of the putative loci for type 2 diabetes.
Robert L, Hanson, William C, Knowler
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Analysis of Quantitative Trait Loci
2008Diseases with complex inheritance are characterized by multiple genetic and environmental factors that often interact to produce clinical symptoms. In addition, etiological heterogeneity (different risk factors causing similar phenotypes) obscure the inheritance pattern among affected relatives and hamper the feasibility of gene-mapping studies.
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Mapping Multiple Quantitative Trait Loci for Ordinal Traits
Behavior Genetics, 2004Many complex traits in humans and other organisms show ordinal phenotypic variation but do not follow a simple Mendelian pattern of inheritance. These ordinal traits are presumably determined by many factors, including genetic and environmental components. Several statistical approaches to mapping quantitative trait loci (QTL) for such traits have been
Nengjun, Yi +3 more
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Epistasis for Quantitative Traits in Drosophila
2014The role of gene-gene interactions in the genetic architecture of quantitative traits is controversial, despite the biological plausibility of nonlinear molecular interactions underpinning variation in quantitative traits. In strictly outbreeding populations, genetic architecture is inferred indirectly by estimating variance components; however ...
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Mapping quantitative trait loci for traits defined as ratios
Genetica, 2007Many traits are defined as ratios of two quantitative traits. Methods of QTL mapping for regular quantitative traits are not optimal when applied to ratios due to lack of normality for traits defined as ratios. We develop a new method of QTL mapping for traits defined as ratios.
Runqing, Yang, Jiahan, Li, Shizhong, Xu
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The evolution of quantitative traits
2023Biologische Evolution lässt kontinuierlich Vielfalt entstehen, welche durch natürliche Selektion in fortwährender Optimierung von biologischen Organismen mündet. Es ist augenscheinlich, dass Lebewesen sichtbare Eigenschaften vorweisen, die maßgeschneidert an ihre jeweilige Umwelt sind.
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Quantitative Traits in Breeding
2017Quantitative traits are those controlled by several genes and are strongly influenced by the environment, presenting continuous distribution, for example, soybean grain yield. Most of the important economic characteristics for the soybean crop are quantitative in nature.
Felipe Lopes da Silva +3 more
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Fine-tuning of quantitative traits
Science China Life Sciences, 2023Luo, Guangbin, Palmgren, Michael
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Molecular quantitative trait loci
Nature Reviews Methods Primers, 2023François Aguet, Yang I Li, Kaur Alasoo
exaly