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CSF‐Compartmentalized Antibody Glycoprofiles in NMDAR Encephalitis Associate with Etiology and Functional Recovery

Annals of Neurology, EarlyView.
Objective To characterize Fc‐glycosylation profiles in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARe) and assess their association with antibody compartmentalization (cerebrospinal fluid [CSF] vs serum), disease triggers (viral, tumor‐related or idiopathic), and 1‐year outcomes.
Laura Marmolejo, Claudia Papi, Chiara Milano, Esther Aguilar, Estibaliz Maudes, Ivana Duvnjak Orešković, Jerko Štambuk, Maja Pučić‐Baković, Gemma Olivé‐Cirera, Elianet Fonseca, Mar Guasp, Eugenia Martinez‐Hernandez, Helena Ariño, Takahiro Iizuka, Thais Armangué, Josep Dalmau, Marianna Spatola   +16 more
wiley   +1 more source

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Common disorders are quantitative traits

Nature Reviews Genetics, 2009
After drifting apart for 100 years, the two worlds of genetics - quantitative genetics and molecular genetics - are finally coming together in genome-wide association (GWA) research, which shows that the heritability of complex traits and common disorders is due to multiple genes of small effect size.
Plomin, Robert, Haworth, Claire M A, Davis, Oliver S P   +2 more
openaire   +5 more sources

Quantitative trait loci in Drosophila

Nature Reviews Genetics, 2001
Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been
Trudy F C Mackay
openaire   +4 more sources

Quantitative trait loci for baseline erythroid traits

Mammalian Genome, 2006
A substantial genetic contribution underlies variation in baseline peripheral blood counts. We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline erythroid parameters in F2 intercrosses between NZW/LacJ, SM/J, and C57BLKS/J inbred mice.
Peters, L L, Lambert, A J, Zhang, W, Churchill, G A, Brugnara, C, Platt, O S   +5 more
openaire   +2 more sources

Quantitative Trait Loci Mapping

2008
This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping.
Dong-Hai, Xiong, Jian-Feng, Liu, Yan-Fang, Guo, Yan, Guo, Tie-Lin, Yang, Hui, Jiang, Yuan, Chen, Fang, Yang, Robert R, Recker, Hong-Wen, Deng   +9 more
openaire   +2 more sources

Quantitative Traits and Quantitative Genetics

2014
In contrast with qualitative or dichotomous traits, quantitative traits are measured using quantitative or semi-quantitative variables and their inheritance is controlled by multiple genes acting independently or in association. Quantitative traits are also influenced to varying degrees by the environment and this explains why they are often designated
Jean-Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli   +3 more
openaire   +1 more source

Quantitative trait loci and psychopharmacology

Journal of Psychopharmacology, 1991
Unlike simple Mendelian characteristics, individual differences in behavior, including behavioral responses to drugs, are generally distributed continuously, show substantial non-genetic as well as genetic influence, and appear to be influenced by many genes rather than one or two major genes.
Plomin, R, McClearn, G E, Gora-Maslak, G
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Multipoint analysis of quantitative traits

Genetic Epidemiology, 1997
Complete multipoint analysis as implemented by MAPMAKER/SIBS was used to identify the chromosomal regions with the strongest evidence of linkage. Three different quantitative sib-pair methods were compared. For each trait the maximum lod/Z score was used to implicate a chromosomal region.
Marlow, A J, John, S, Worthington, J
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Quantitative Trait Dissection

2019
The inheritance of phenotypes (traits) in any organism can generally be classified in either of two ways: (1) those inherited by a single gene and (2) those inherited from multiple genes. Multiple terms have been used to describe these two conditions.
David B. Neale, Nicholas C. Wheeler
openaire   +1 more source