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Parameters of Quantitative Trait Loci
Critical Reviews™ in Eukaryotic Gene Expression, 2007Most traits of medical relevance follow quantitative inheritance patterns. The genetic dissection of quantitative traits poses special challenges for geneticists mainly because of low penetrance and gene-gene and gene-environment interactions. Emerging genome resources and technologies are enabling systematic investigation of the genetic architecture ...
Jian, Yan, Weikuan, Gu
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Quantitative trait linkage studies of diabetes-related traits
Current Diabetes Reports, 2003Genetic linkage methods for diseases with complex inheritance are based on assessment of allele sharing between affected relative pairs, but such methods have low power to detect genes with moderate effects. This may explain the difficulty in replication for many of the putative loci for type 2 diabetes.
Robert L, Hanson, William C, Knowler
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Mapping Multiple Quantitative Trait Loci for Ordinal Traits
Behavior Genetics, 2004Many complex traits in humans and other organisms show ordinal phenotypic variation but do not follow a simple Mendelian pattern of inheritance. These ordinal traits are presumably determined by many factors, including genetic and environmental components. Several statistical approaches to mapping quantitative trait loci (QTL) for such traits have been
Nengjun, Yi +3 more
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Quantitative trait loci for behavioural traits in chickens
Livestock Production Science, 2005Abstract The detection of quantitative trait loci (QTL) of behavioural traits has mainly been focussed on mouse and rat. With the rapid development of molecular genetics and the statistical tools, QTL mapping for behavioural traits in farm animals is developing.
Buitenhuis, A.J. +9 more
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1995
The preceding chapters demonstrate the utility of behavior genetic methodology and the twin/family study design for determining etiological components of traits of medical and behavioral importance. Knowledge of the relative influence of genetic and environmental determinants, their developmental patterns, their different manifestations in males and ...
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The preceding chapters demonstrate the utility of behavior genetic methodology and the twin/family study design for determining etiological components of traits of medical and behavioral importance. Knowledge of the relative influence of genetic and environmental determinants, their developmental patterns, their different manifestations in males and ...
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Analysis of Quantitative Trait Loci
2008Diseases with complex inheritance are characterized by multiple genetic and environmental factors that often interact to produce clinical symptoms. In addition, etiological heterogeneity (different risk factors causing similar phenotypes) obscure the inheritance pattern among affected relatives and hamper the feasibility of gene-mapping studies.
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Analysis of Quantitative Trait Loci
2016Although the term quantitative trait locus (QTL) strictly refers merely to a genetic variant that causes changes in a quantitative phenotype such as height, QTL analysis more usually describes techniques used to study oligogenic or polygenic traits where each identified locus contributes a relatively small amount to the genetic determination of the ...
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2010
In plants, most of the phenotypic variations are continuously distributed and could be considered as quantitative traits. The complexity of their genetic control is high because the involved genes are numerous, with usually minor effects and very sensitive to environment.
Ikram, Sobia, Chardon, Fabien
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In plants, most of the phenotypic variations are continuously distributed and could be considered as quantitative traits. The complexity of their genetic control is high because the involved genes are numerous, with usually minor effects and very sensitive to environment.
Ikram, Sobia, Chardon, Fabien
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Quantitative Trait Loci (QTL) Mapping
2019Quantitative trait loci (QTL) are genetic regions that influence phenotypic variation of a complex trait, often through genetic interactions with each other and the environment. These are commonly identified through a statistical genetic analysis known as QTL mapping. Here, I present a step-by-step, practical approach to QTL mapping along with a sample
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