Results 11 to 20 of about 18,939 (195)

Viral quasispecies.

PLoS Genetics, 2019
Viral quasispecies refers to a population structure that consists of extremely large numbers of variant genomes, termed mutant spectra, mutant swarms or mutant clouds.
Esteban Domingo, Celia Perales
doaj   +5 more sources

Pre-S Deletions are Predominant Quasispecies in HIV/HBV Infection: Quasispecies Perspective

Infection and Drug Resistance, 2020
Yuan Nie,1,2,* Xi-Zi Deng,1,* Yun Lan,1 Feng Li,1 Feng-Yu Hu1 1Research Institute, Guangzhou Eighth People’s Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 2Department of ...
Nie Y, Deng XZ, Lan Y, Li F, Hu FY
doaj   +3 more sources

Adaptive Evolution and Distinct Mutation Signatures of Full-Length HBV Quasispecies in HBeAg-Negative Chronic Hepatitis B. [PDF]

Microbiologyopen
HBeAg‐negative chronic hepatitis B harbors a highly heterogeneous HBV quasispecies shaped by region‐specific selection. Adaptive strategies underpinning viral persistence include: BCP/PreC mutations supporting replication, PreS/S mutations enabling immune evasion, and overlapping Pol/S mutations maintaining viral fitness.
Wu C, Liu F, Li X, Li X, Li H, Zhang S, Yan X, Zhou T, Wei J.   +8 more
europepmc   +2 more sources

Natural occurrence of drug resistance mutations to the HIV-1 capsid inhibitor lenacapavir. [PDF]

HIV Med
Abstract Aims Lenacapavir (LEN) is a first‐in‐class HIV‐1 capsid inhibitor. We investigated the natural occurrence of LEN drug resistance mutations (DRM) in HIV‐1 sequences from LEN treatment‐naïve individuals. Methods We analysed all available HIV‐1 capsid sequences (n = 21 646) from individuals never exposed to LEN from the Los Alamos National ...
Weibull Wärnberg A, Ceña-Diez R, Sönnerborg A, van de Klundert MAA.   +3 more
europepmc   +2 more sources

HIV-1 quasispecies delineation by tag linkage deep sequencing. [PDF]

PLoS ONE, 2014
Trade-offs between throughput, read length, and error rates in high-throughput sequencing limit certain applications such as monitoring viral quasispecies.
Nicholas C Wu, Justin De La Cruz, Laith Q Al-Mawsawi, C Anders Olson, Hangfei Qi, Harding H Luan, Nguyen Nguyen, Yushen Du, Shuai Le, Ting-Ting Wu, Xinmin Li, Martha J Lewis, Otto O Yang, Ren Sun   +13 more
doaj   +1 more source

Stochastic simulations suggest that HIV-1 survives close to its error threshold. [PDF]

PLoS Computational Biology, 2012
The use of mutagenic drugs to drive HIV-1 past its error threshold presents a novel intervention strategy, as suggested by the quasispecies theory, that may be less susceptible to failure via viral mutation-induced emergence of drug resistance than ...
Kushal Tripathi, Rajesh Balagam, Nisheeth K Vishnoi, Narendra M Dixit   +3 more
doaj   +1 more source

Intra-Host Diversity of Dengue Virus in Mosquito Vectors

Frontiers in Cellular and Infection Microbiology, 2022
Dengue virus (DENV) is the most common arbovirus, causing a significant burden on both the economy and global healthcare systems. The virus is transmitted by Aedes species of mosquitoes as a swarm of closely related virus genomes, collectively referred ...
Amanda Makha Bifani, Tanamas Siriphanitchakorn, Milly M. Choy   +2 more
doaj   +1 more source

Quasispecies Made Simple

PLoS Computational Biology, 2005
Quasispecies are clouds of genotypes that appear in a population at mutation-selection balance. This concept has recently attracted the attention of virologists, because many RNA viruses appear to generate high levels of genetic variation that may enhance the evolution of drug resistance and immune escape. The literature on these important evolutionary
Bull, J., Meyers, L., Lachmann, M.
openaire   +7 more sources

Modeling viral coevolution: HIV multi-clonal persistence and competition dynamics [PDF]

, 2005
The coexistence of different viral strains (quasispecies) within the same host are nowadays observed for a growing number of viruses, most notably HIV, Marburg and Ebola, but the conditions for the formation and survival of new strains have not yet been ...
Altfeld, Bagnoli, Bello, Blackard, Burch, Celada, Chao, Costa, De Boer, De Boer, Eigen, Eigen, F. Bagnoli, Franz, Galvani, Gerhardt, Gog, Haaft, Ho, Jenkins, Jetzt, Kijak, Krempl, L. Sguanci, Levy, Lin, Lio, Mansky, Miller, Neumann, P. Liò, Pantaleo, Parkin, Perelson, Perelson, Ramos, Revilla, Schnell, Shankarappa, Wei, Wiegel, Wodarz1, Yang, Zanotto   +43 more
core   +2 more sources

Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies [PDF]

, 2013
Following long-term infection with virus derived from the pathogenic GL8 molecular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct modes of interaction with the viral receptors CD134 and CXCR4, and ...
A de Parseval, A Samman, AJ Marozsan, Alfred L. Roca, BJ Willett, BJ Willett, BJ Willett, BJ Willett, BJ Willett, BJ Willett, BJ Willett, BJ Willett, Brian J. Willett, C Munk, CE Lawrence, Elizabeth McMonagle, G Pantaleo, G Ryan, GA Dean, GA Dean, GA Dean, HR Rangel, JD Wilson, JJ Callanan, JJ Callanan, JJ Callanan, JK Yamamoto, JK Yamamoto, JN Flynn, KH Siebelink, KHJ Siebelink, L Margolis, LJ Diehl, M Bendinelli, M Hosie, M Kraase, M Pistello, M Shimojima, M Shimojima, Margaret J. Hosie, Mariana Varela, Martin Kraase, MJ Hosie, MJ Hosie, Nicola Logan, P Borrow, R Paillot, R Pu, R Pu, RA Koup, RI Connor, RV English, S Giannecchini, SC Ball, SP Dunham, TM Miyazawa, UK Laemmli, Y Inoshima, Y Nishimura   +58 more
core   +3 more sources