Results 41 to 50 of about 18,939 (195)
Random matrices and localization in the quasispecies theory
, 2011 The quasispecies model of biological evolution for asexual organisms such as bacteria and viruses has attracted considerable attention of biological physicists.
Waclaw, Bartlomiej
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Virology Journal, 2006 Background/Aim Hepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease has emerged.
Cristina Juan +3 more
doaj +1 more source
Therapy Implications of Hepatitis C Virus Genetic Diversity
Viruses, 2020 Hepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection, which carries the risk of progression to hepatic fibrosis, cirrhosis, and ...
Miguel Angel Martinez, Sandra Franco
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Co-Evolution of quasispecies: B-cell mutation rates maximize viral error catastrophes
, 2001 Co-evolution of two coupled quasispecies is studied, motivated by the competition between viral evolution and adapting immune response. In this co-adaptive model, besides the classical error catastrophe for high virus mutation rates, a second ...
A. Aigner +29 more
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Quasispecies on class-dependent fitness landscapes [PDF]
, 2016 We study Eigen's quasispecies model in the asymptotic regime where the length of the genotypes goes to infinity and the mutation probability goes to 0. We give several explicit formulas for the stationary solutions of the limiting system of differential ...
Cerf, Raphaël, Dalmau, Joseba
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International Journal of Infectious Diseases, 2021 Objectives: Human immunodeficiency virus (HIV) quasispecies diversity presents a large barrier to the eradication of HIV. The aim of this study was to investigate intrahost HIV quasispecies diversity and evolutionary patterns underpinning the mechanisms ...
Yuanyuan Zhang +11 more
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Phase Diagrams of Quasispecies Theory with Recombination and Horizontal Gene Transfer
, 2006 We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution.
J. Maynard +4 more
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Dynamics and bifurcations in a simple quasispecies model of tumorigenesis [PDF]
, 2014 Cancer is a complex disease and thus is complicated to model. However, simple models that describe the main processes involved in tumoral dynamics, e.g., competition and mutation, can give us clues about cancer behaviour, at least qualitatively, also ...
Castillo, V. +2 more
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Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, Volume 16, Issue 5, Page 821-836, May 2026.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
From Quasispecies Theory to Viral Quasispecies: How Complexity has Permeated Virology [PDF]
Mathematical Modelling of Natural Phenomena, 2012 Peer ...
Domingo, Esteban, Perales, Celia
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