Results 61 to 70 of about 18,939 (195)

Error threshold in finite populations

, 1998
A simple analytical framework to study the molecular quasispecies evolution of finite populations is proposed, in which the population is assumed to be a random combination of the constiyuent molecules in each generation,i.e., linkage disequilibrium at ...
A. Prügel-Bennett, D. Alves, D. Alves, D. Alves, D. E. Goldberg, D. Gillespie, D. Gillespie, E. van Nimwegen, G. Woodcock, H. Inagaki, I. Leuthäusser, I. Leuthäusser, J. F. Fontanari, J. Maynard Smith, J. S. McCaskill, J. Swetina, M. Eigen, M. Eigen, M. Nowak, M. W. Feldman, P. G. Higgs, P. Tarazona, S. Galluccio, S. Galluccio, T. Wiehe, W. Ebeling, W. Gabriel, Y-C. Zhang   +27 more
core   +1 more source

Quantifying In-Host Quasispecies Evolution

International Journal of Molecular Sciences, 2023
What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and
Josep Gregori, Marta Ibañez-Lligoña, Josep Quer   +2 more
openaire   +5 more sources

Hepatitis B Virus Genomic Variability & HBV‐Related Disease Outcomes: A Molecular Epidemiology Perspective

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT HBV infection remains a major global health challenge, characterized by diverse genotypes with distinct geographical distributions and clinical outcomes. Comprehensive analysis of HBV genomic variability and its association with disease progression is essential for improving clinical management and public health strategies. This study aimed to
Maria Bousali, George Papatheodoridis, Magdalini Bletsa, Dimitrios Paraskevis, Timokratis Karamitros   +4 more
wiley   +1 more source

Finite-size scaling of the quasiespecies model

, 1998
We use finite-size scaling to investigate the critical behavior of the quasiespecies model of molecular evolution in the single-sharp-peak replication landscape. This model exhibits a sharp threshold phenomenon at Q=Q_c=1/a, where Q is the probability of
D. Alves, I. Leuthäusser, I. Leuthäusser, J. F. Fontanari, J. Swetina, K. Binder, M. Eigen, M. Eigen, M. N. Barber, P. R. A. Campos, P. Tarazona, S. Galluccio, S. Kirkpatrick, T. Wiehe   +13 more
core   +1 more source

“Fertile” Mutations in SARS‐CoV‐2 RNA More Frequently Occurred in Hairpin Loops That Determine Virus Evolution

APMIS, Volume 133, Issue 12, December 2025.
ABSTRACT RNA hairpins may constitute a foundation of genetic evolution both in viruses and other organisms. Stem‐loops theoretically comprise a stable part, the double‐stranded stem, and a single‐stranded loop allowing evolution. Here we tested for SARS‐CoV‐2 if “fertile” mutations were in loops while mutations in stems were poorly tolerated and rarely
Philippe Colson, Pierre Pontarotti, Jacques Fantini, Anthony Levasseur, Christian Devaux, Didier Raoult   +5 more
wiley   +1 more source

RNA Viruses and RNAi: Quasispecies Implications for Viral Escape

Viruses, 2015
Due to high mutation rates, populations of RNA viruses exist as a collection of closely related mutants known as a quasispecies. A consequence of error-prone replication is the potential for rapid adaptation of RNA viruses when a selective pressure is ...
John B. Presloid, Isabel S. Novella
doaj   +1 more source

The dynamic variation position and predominant quasispecies of hepatitis B virus: Novel predictors of early hepatocarcinoma

Virus Research
To find the predictors of early HCC based on the dynamic changes of HBV quasispecies, this study utilizing the second-generation sequencing (NGS) and high-order multiplex droplet digital PCR (ddPCR) technology to examine the HBV quasispecies in serum of ...
Chaojun Zhang, Sanchun An, Ruibo Lv, Kezhi Li, Haizhou Liu, Jilin Li, Yanping Tang, Zhengmin Cai, Tianren Huang, Long Long, Wei Deng   +10 more
doaj   +1 more source

Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants

Viruses, 2015
Within-host genetic sequencing from samples collected over time provides a dynamic view of how viruses evade host immunity. Immune-driven mutations might stimulate neutralization breadth by selecting antibodies adapted to cycles of immune escape that ...
Peter Hraber, Bette Korber, Kshitij Wagh, Elena E. Giorgi, Tanmoy Bhattacharya, S. Gnanakaran, Alan S. Lapedes, Gerald H. Learn, Edward F. Kreider, Yingying Li, George M. Shaw, Beatrice H. Hahn, David C. Montefiori, S. Munir Alam, Mattia Bonsignori, M. Anthony Moody, Hua-Xin Liao, Feng Gao, Barton F. Haynes   +18 more
doaj   +1 more source

Quasispecies distribution of Eigen model

, 2006
We study sharp peak landscapes (SPL) of Eigen model from a new perspective about how the quasispecies distribute in the sequence space. To analyze the distribution more carefully, we bring forth two tools.
Campos P R A, Chen Jia, Franz S, Hu K, Li Sheng, Li Y, Liu H K, Ma Hong-Ru, Pan Z F, Wu J J   +9 more
core   +2 more sources

Characteristic time in quasispecies evolution [PDF]

Journal of Theoretical Biology, 2012
The time a phenotype takes to achieve a stationary state from an initial condition depends on multiple factors. In particular, it is a function of both its fitness and its mutation rate. We evaluate the average time, referred to as the characteristic time, T(c), that the system takes to reach a final steady state of simple models of populations formed ...
Sanz Nuño, Juan Carlos, Marin, Arturo, Tejero, Hector, Montero, Francisco   +3 more
openaire   +4 more sources