Results 51 to 60 of about 18,939 (195)
Journal of Medical Virology, Volume 98, Issue 1, January 2026.ABSTRACT Lenacapavir (LEN) is a first‐in‐class capsid inhibitor (CAI) that targets multiple stages of the HIV‐1 lifecycle, showing efficacy in heavily treatment‐experienced (HTE) individuals with multidrug‐resistance (MDR) and in pre‐exposure prophylaxis (PrEP). This study aimed to characterize a novel in‐house next‐generation sequencing (NGS) protocol
Omar El Khalili +10 more
wiley +1 more source
Risk factors associated with viral nervous necrosis in hybrid groupers in Malaysia and the high similarity of its causative agent nervous necrosis virus to reassortant red-spotted grouper nervous necrosis virus/striped jack nervous necrosis virus strains [PDF]
Veterinary World, 2019 Background and Aim: Viral nervous necrosis (VNN) is a serious disease of several marine fish species. VNN causes 100% mortality in the larval stages, while lower losses have been reported in juvenile and adult fish.
Nurshuhada Ariff +4 more
doaj +1 more source
The intermediate evolution phase in case of truncated selection
, 2009 Using methods of statistical physics, we present rigorous theoretical calculations of Eigen's quasispecies theory with the truncated fitness landscape which dramatically limits the available sequence space of a reproducing quasispecies.
A. Melikyan +9 more
core +1 more source
Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-Naïve chronic HBV patients [PDF]
, 2013 Background: Immunomodulators and Nucleotide analogues have been used globally for the dealing of chronic hepatitis B virus (HBV) infection. However, the development of drug resistance is a major limitation to their long-term effectiveness.
Abedi, F. +33 more
core +1 more source
Challenges in Diagnosing and Managing Hepatitis E in Transplant Recipients: A Case Report
Case Reports in Transplantation, Volume 2026, Issue 1, 2026.Hepatitis E virus (HEV) is a common but often underdiagnosed cause of hepatitis in both the general population and transplant patients. Diagnosis is usually made by detecting IgM anti‐HEV antibodies, with immunosuppressed individuals being at higher risk for chronic infection.
Ana Cristina Martins +6 more
wiley +1 more source
The Importance of DNA Repair in Tumor Suppression
, 2004 The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions.
B. Vogelstein +8 more
core +1 more source
Stem-Like Adaptive Aneuploidy and Cancer Quasispecies [PDF]
, 2013 We analyze and reinterpret experimental evidence from the literature to argue for an ability of tumor cells to self-regulate their aneuploidy rate. We conjecture that this ability is mediated by a diversification factor that exploits molecular mechanisms
Napoletani, Domenico +2 more
core +4 more sources
Quasispecies Theory in Virology [PDF]
Journal of Virology, 2002 Holmes and Moya claim that quasispecies is an unnecessary and misleading description of RNA virus evolution, that virologists refer to quasispecies inappropriately, and that there is little evidence of quasispecies in RNA virus evolution. They wish to look for other ideas in evolutionary biology and to set down an agenda for future research.
openaire +2 more sources
Fidelity Variants and RNA Quasispecies [PDF]
, 2015 By now, it is well established that the error rate of the RNA-dependent RNA polymerase (RdRp) that replicates RNA virus genomes is a primary driver of the mutation frequencies observed in RNA virus populations-the basis for the RNA quasispecies.
Bordería, Antonio V. +2 more
openaire +2 more sources
EFSA Journal, Volume 24, Issue 1, January 2026.Abstract The qualified presumption of safety (QPS) process was developed to provide a harmonised safety assessment approach to support EFSA Scientific Panels and Units. The QPS approach assesses the taxonomic identity, body of relevant knowledge and safety concerns of microorganisms intentionally added to the food and feed chain.
EFSA Panel on Biological Hazards (BIOHAZ) +28 more
wiley +1 more source