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Memory in Viral Quasispecies [PDF]
Journal of Virology, 2000 ABSTRACT Biological adaptive systems share some common features: variation among their constituent elements and continuity of core information. Some of them, such as the immune system, are endowed with memory of past events. In this study we provide direct evidence that evolving viral quasispecies possess a molecular memory in the form of ...
Ruiz-Jarabo, Carmen M. +4 more
openaire +3 more sources
Inferring viral quasispecies spectra from 454 pyrosequencing reads
BMC Bioinformatics, 2011 Background RNA viruses infecting a host usually exist as a set of closely related sequences, referred to as quasispecies. The genomic diversity of viral quasispecies is a subject of great interest, particularly for chronic infections, since it can lead ...
Măndoiu Ion +6 more
doaj +1 more source
Viral quasispecies profiles as the result of the interplay of competition and cooperation
BMC Evolutionary Biology, 2010 Background Viral quasispecies can be regarded as a swarm of genetically related mutants. A common approach employed to describe viral quasispecies is by means of the quasispecies equation (QE).
Fort Hugo, Mirazo Santiago, Arbiza Juan
doaj +1 more source
Scientific Reports, 2021 Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication.
Maria Francesca Cortese +18 more
doaj +1 more source
Intra-Host Diversity of SARS-Cov-2 Should Not Be Neglected: Case of the State of Victoria, Australia
Viruses, 2021 Since the identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the etiological agent of the current COVID-19 pandemic, a rapid and massive effort has been made to obtain the genomic sequences of this virus to monitor (in near
Alix Armero +2 more
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Field theory for a reaction-diffusion model of quasispecies dynamics [PDF]
, 2001 RNA viruses are known to replicate with extremely high mutation rates. These rates are actually close to the so-called error threshold. This threshold is in fact a critical point beyond which genetic information is lost through a second-order phase ...
A. B. van’t Wout +26 more
core +3 more sources
Virology Journal, 2008 Pre-treatment HCV quasispecies complexity and diversity may predict response to interferon based anti-viral therapy. The objective of this study was to retrospectively (1) examine temporal changes in quasispecies prior to the start of therapy and (2 ...
Kenny-Walsh Elizabeth +4 more
doaj +1 more source
Mathematical Model of HIV superinfection dynamics and R5 to X4 switch [PDF]
, 2006 During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively).
Bagnoli, Franco +2 more
core +1 more source
Selective Diversity in RNA Viruses: Do They Know How to Evolve? A Hypothesis. [PDF]
BioessaysAmong many sophisticated things viruses “learned” during their evolution, could be a simple mechanism for preferential accumulation of genetic variability in regions beneficial for virus survival. Identification of the major players coordinating this selective diversity could find applications in the development of effective prophylactic and ...
Nemchinov LG.
europepmc +2 more sources
Quasispecies theory in the context of population genetics
BMC Evolutionary Biology, 2005 Background A number of recent papers have cast doubt on the applicability of the quasispecies concept to virus evolution, and have argued that population genetics is a more appropriate framework to describe virus evolution than quasispecies theory ...
Wilke Claus O
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