Results 61 to 70 of about 325,836 (358)

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

What, if Anything, is Quaternary?

Episodes, 2009
The formal recognition of Quaternary as a Period/ System was approved by IUGS in June 2009, in accordance with a proposal originated by INQUA. There are reasons to believe that this will have destabilizing consequences for the geological time scale. Until now, the primary divisions of the stratigraphic record, at the Period level and above, have been ...
William A. Berggren, Lucas Joost Lourens, Marie-Pierre Aubry, Felix M. Gradstein, Frits Hilgen, John A. Van Couvering, Dennis V. Kent, Brian McGowran   +7 more
openaire   +4 more sources

Academician Vladimir Laskarev (1868-1954) and Paratethys [PDF]

Geološki Anali Balkanskoga Poluostrva
Vladimir Laskarev (1868–1954) Russian and Serbian geologist strongly influenced geological literature by introducing a scientific term Paratethys for the series of intercontinental water basins separated from the Mediterranean Sea and the World Ocean by ...
Malakhova Irina, Tesakov Alexey, Popov Sergey, Rundić Ljupko   +3 more
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Hydroalkylation of Olefins To Form Quaternary Carbons.

Journal of the American Chemical Society, 2019
Metal-hydride hydrogen atom transfer (MHAT) functionalizes alkenes with predictable branched (Markovnikov) selectivity. The breadth of these transformations has been confined to π-radical traps; no sp3 electrophiles have been reported. Here we describe a
Samantha A. Green, Tucker R Huffman, Ruairi O. McCourt, Vincent van der Puyl, R. Shenvi   +4 more
semanticscholar   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

The cytochrome oxidase defect in ISC‐depleted yeast is caused by impaired iron–sulfur cluster maturation of the mitoribosome assembly factor Rsm22

FEBS Letters, EarlyView.
The yeast mitoribosome assembly factor Rsm22 contains a [4Fe‐4S] cluster that is matured by the mitochondrial iron–sulfur cluster assembly (ISC) machinery. Defects in ISC components result in impaired mitochondrial protein synthesis due to a mitoribosome assembly defect.
Ulrich Mühlenhoff, Dominik Trauth, Weronika Śliwińska, Linda Boss, Roland Lill   +4 more
wiley   +1 more source

Quaternary

Abstract During the Quaternary (last 2.58 Myr) polycyclic and progressive climate shifts controlled depositional systems in the southern North Sea region and shaped today’s Dutch landscapes. Continuous sediment supply from surrounding regions and strong basin subsidence resulted in thick depositional sequences that recorded information on successive ...
Busschers, F., Cohen, K., Wesselingh, F., Bakker, M., Schokker, J., Balen, R. van, Heteren, S. van   +6 more
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source