Results 41 to 50 of about 225,993 (289)

Self-quenched dynamics [PDF]

The European Physical Journal B, 2000
We introduce a model for the slow relaxation of an energy landscape caused by its local interaction with a random walker whose motion is dictated by the landscape itself. By choosing relevant measures of time and potential this self-quenched dynamics can be mapped on to the ``True'' Self-Avoiding Walk model. This correspondence reveals that the average
Torok, Janos, Krishnamurthy, Supriya, Kertesz, Janos, Roux, Stephane   +3 more
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Determination of Trace ⁵⁵Fe and ⁶³Ni in Steel Samples via Liquid Scintillation Counting

Applied Sciences
In the decommissioning of nuclear facilities, activated steel often contains radionuclides such as 55Fe and 63Ni, which are categorized as hard-to-measure due to their emission of only low-energy beta particles or X-rays.
Giada Gandolfo, Maria Letizia Cozzella, Tiziana Guarcini, Giuseppe Augusto Marzo   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Luminescent Oxygen Gas Sensors Based on Nanometer-Thick Hybrid Films of Iridium Complexes and Clay Minerals

Chemosensors, 2014
The use of Ir(III) complexes in photo-responsive molecular devices for oxygen gas sensing is reviewed. Attention is focused on the immobilization of Ir(III) complexes in organic or inorganic host materials such as polymers, silica and clays in order to ...
Hisako Sato, Kenji Tamura, Akihiko Yamagishi   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Effect of Graphite and Activated Carbon as Dispersed Particle in Base Fluid as Quench Medium on the Hardness of S45C Carbon Steel

Journal of Materials Exploration and Findings, 2023
Adding a solid particle dispersion into a base fluid could increase its thermal conductivity, hence increasing the heat transfer characteristics. One example of this thermally enhanced fluid is in heat treatment industry as quench medium.
Wahyuaji Narottama Putra, Danika Aprilia Somadinata, Ghiska Ramahdita   +2 more
doaj   +1 more source

Calculating quenching weights [PDF]

Physical Review D, 2003
We calculate the probability (``quenching weight'') that a hard parton radiates an additional energy fraction due to scattering in spatially extended QCD matter. This study is based on an exact treatment of finite in-medium path length, it includes the case of a dynamically expanding medium, and it extends to the angular dependence of the medium ...
Salgado, Carlos A., Wiedemann, Urs Achim
openaire   +2 more sources