Results 61 to 70 of about 281,649 (291)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Luminescent Oxygen Gas Sensors Based on Nanometer-Thick Hybrid Films of Iridium Complexes and Clay Minerals

Chemosensors, 2014
The use of Ir(III) complexes in photo-responsive molecular devices for oxygen gas sensing is reviewed. Attention is focused on the immobilization of Ir(III) complexes in organic or inorganic host materials such as polymers, silica and clays in order to ...
Hisako Sato, Kenji Tamura, Akihiko Yamagishi   +2 more
doaj   +1 more source

A novel 2-D mathematical modeling to determine LHP to protect the industrial transient heat treatment quenched low carbon steels bar

Zaštita Materijala, 2023
2-dimensional mathematical model of axisymmetric transient industrial quenched low carbon steel bar, to examine the influence of process history on metallurgical and material characteristics, a water-cooled model based on the finite element technique was
Abdlmanam S.A. Elmaryami, Amal A.E. Mohamed   +1 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Quenching-Induced Structural Distortion of Graphitic Carbon Nitride Nanostructures: Enhanced Photocatalytic Activity and Electrochemical Hydrogen Production

, 2019
Engineered nanomaterials are emerging in the field of environmental chemistry. This study involves the analysis of the structural, electronic, crystallinity, and morphological changes in graphitic carbon nitride (g-C3N4), an engineered nanomaterial ...
Arulappan Durairaj (6567500), Subramanian Ramanathan (6567506), Samuel Vasanthkumar (807394), Thangavel Sakthivel (6567503)   +3 more
core   +1 more source

Study of factors controlling the photoprotection capacity of the thylakoid membrane [PDF]

, 2010
PhDPlants require light for the process of photosynthesis, but excess of light absorption can cause photooxidative damage. To avoid this damage, plants have evolved a photoprotective mechanism to dissipate excess light energy as heat in a process ...
Zia, Ahmad
core   +4 more sources

Interrupted quenching in high carbon steels for forgings

Metalurgija, 2017
The present study is focused on analyzing the effect of the interrupted quenching followed by a partitioning process in a high carbon steel 0,50 % C, 1,50 % Mn, 0,40 % Si, 2,00 % Cr without significant contribution of Al.
G. Napoli, S. Mengaroni, M. Rallini, L. Torre, A. Di Schino   +4 more
doaj  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source