Results 41 to 50 of about 173,210 (259)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A single quenching point for a fractional heat equation based on the Riemann-Liouville fractional derivative with a nonlinear concentrate source

Boundary Value Problems, 2017
This paper aims to study the quenching problem in a fractional heat equation with the Riemann-Liouville fractional derivative. The existence and uniqueness of a solution for the problem are obtained by transforming the problem to an equivalent integral ...
Wannika Sawangtong, Panumart Sawangtong
doaj   +1 more source

Quenching Behavior of the Electrochemiluminescence of Ru(bpy)32+/TPrA System by Phenols on a Smartphone‐Based Sensor

ChemistryOpen, 2021
Phenolic compounds such as vanillic and p‐coumaric acids are pollutants of major concern in the agro‐industrial processing, thereby their effective detection in the industrial environment is essential to reduce exposure.
Dr. Elmer C. Rivera, Joseph W. Taylor, Dr. Rodney L. Summerscales, Dr. Hyun J. Kwon   +3 more
doaj   +1 more source

Improved Sample Preparation for Untargeted Metabolomics Profiling of Escherichia coli

Microbiology Spectrum, 2021
Metabolomics is a powerful tool that can systematically describe global changes in the metabolome of microbes, thus improving our understanding of the mechanisms of action of antibiotics and facilitating the development of next-generation antibacterial ...
Dongyang Ye, Xiaowei Li, Chengfei Wang, Saiwa Liu, Liang Zhao, Jingjing Du, Jian Xu, Jing Li, Lu Tian, Xi Xia   +9 more
doaj   +1 more source

Modelling jet quenching with Quenching Weights

Journal of Physics: Conference Series, 2015
We present a phenomenological study of the single- and double-inclusive suppression data of high-pT particles in central Pb-Pb collisions at LHC. The analysis is based on quenching weights for medium-induced gluon radiation computed in the multiple soft scattering approximation and embedded in a hydrodynamic description of the bulk medium.
C Andrés, N Armesto, Carlos A Salgado, Yan Zhu   +3 more
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Determination of Trace ⁵⁵Fe and ⁶³Ni in Steel Samples via Liquid Scintillation Counting

Applied Sciences
In the decommissioning of nuclear facilities, activated steel often contains radionuclides such as 55Fe and 63Ni, which are categorized as hard-to-measure due to their emission of only low-energy beta particles or X-rays.
Giada Gandolfo, Maria Letizia Cozzella, Tiziana Guarcini, Giuseppe Augusto Marzo   +3 more
doaj   +1 more source

A novel 2-D mathematical modeling to determine LHP to protect the industrial transient heat treatment quenched low carbon steels bar

Zaštita Materijala, 2023
2-dimensional mathematical model of axisymmetric transient industrial quenched low carbon steel bar, to examine the influence of process history on metallurgical and material characteristics, a water-cooled model based on the finite element technique was
Abdlmanam S.A. Elmaryami, Amal A.E. Mohamed   +1 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source