Results 51 to 60 of about 291,870 (258)

STRUKTUR MIKRO DAN KEKERASAN BAJA S45C PADA PENGELASAN SMAW DENGAN VARIASI MEDIA QUENCH

JIPTEK: Jurnal Ilmiah Pendidikan Teknik dan Kejuruan, 2019
The purpose of this research is to find out the effect of current on microstructure and hardness value in S45C steel before (raw material) and after welding using Shielded Metal Arc Welding (SMAW). This research using experiment method.
Nizam Effendi
doaj   +1 more source

Water in Deep Eutectic Solvents: New Insights From Inelastic Neutron Scattering Spectroscopy

Frontiers in Physics, 2022
The effect of water on the physicochemical properties of deep eutectic solvents (DES) is a trending research topic. In this work, inelastic neutron scattering (INS) spectroscopy, was used to probe intermolecular interactions in the water-deep eutectic ...
Mariela M. Nolasco, Sónia N. Pedro, Carla Vilela, Pedro D. Vaz, Paulo Ribeiro-Claro, Svemir Rudić, Stewart F. Parker, Carmen S.R. Freire, Mara G. Freire, Armando J. D. Silvestre   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A single quenching point for a fractional heat equation based on the Riemann-Liouville fractional derivative with a nonlinear concentrate source

Boundary Value Problems, 2017
This paper aims to study the quenching problem in a fractional heat equation with the Riemann-Liouville fractional derivative. The existence and uniqueness of a solution for the problem are obtained by transforming the problem to an equivalent integral ...
Wannika Sawangtong, Panumart Sawangtong
doaj   +1 more source

Quenching Behavior of the Electrochemiluminescence of Ru(bpy)32+/TPrA System by Phenols on a Smartphone‐Based Sensor

ChemistryOpen, 2021
Phenolic compounds such as vanillic and p‐coumaric acids are pollutants of major concern in the agro‐industrial processing, thereby their effective detection in the industrial environment is essential to reduce exposure.
Dr. Elmer C. Rivera, Joseph W. Taylor, Dr. Rodney L. Summerscales, Dr. Hyun J. Kwon   +3 more
doaj   +1 more source

Improved Sample Preparation for Untargeted Metabolomics Profiling of Escherichia coli

Microbiology Spectrum, 2021
Metabolomics is a powerful tool that can systematically describe global changes in the metabolome of microbes, thus improving our understanding of the mechanisms of action of antibiotics and facilitating the development of next-generation antibacterial ...
Dongyang Ye, Xiaowei Li, Chengfei Wang, Saiwa Liu, Liang Zhao, Jingjing Du, Jian Xu, Jing Li, Lu Tian, Xi Xia   +9 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Determination of Trace ⁵⁵Fe and ⁶³Ni in Steel Samples via Liquid Scintillation Counting

Applied Sciences
In the decommissioning of nuclear facilities, activated steel often contains radionuclides such as 55Fe and 63Ni, which are categorized as hard-to-measure due to their emission of only low-energy beta particles or X-rays.
Giada Gandolfo, Maria Letizia Cozzella, Tiziana Guarcini, Giuseppe Augusto Marzo   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source