Results 301 to 310 of about 183,299 (371)

Differential Effects of Wild Blueberry (Poly)Phenol Metabolites in Modulating Lipid Metabolism and Oxidative Stress in 3T3‐L1 Adipocytes

open access: yesMolecular Nutrition &Food Research, EarlyView.
Metabolites derived from wild blueberry (poly)phenols, such as syringic (SA), vanillic (VA), and isoferulic acids (IA), can modulate lipid metabolism and oxidative stress markers in mature 3T3‐L1 adipocytes treated with free fatty acids (FFAs; oleic/palmitic acid, 750 µM, 2:1 ratio).
Samuele Venturi   +5 more
wiley   +1 more source

The inhibitory action of quercetin on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells

open access: bronze, 2001
Mya Mya Mu   +7 more
openalex   +1 more source

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

open access: yesNeuroprotection, EarlyView.
Downregulation of the expression of silent information regulator sirtuin 1 (SIRT1) exacerbates neuronal degeneration and loss by activating forkhead box O1 (FOXO1) acetylation and promoting endoplasmic reticulum stress (ERSA)‐mediated apoptosis in aging.
Nan Zhang   +20 more
wiley   +1 more source

In Vitro, Anti‐Colon Cancer Activity of Green Dumbbell‐Shaped Rhododendron luteum‐Based Carbon Dots

open access: yesChemistryOpen, EarlyView.
The anticancer potential of Rhododendron luteum‐based carbon dots was investigated. Environmentally friendly synthesis yielded carbon dots that selectively induced cytotoxicity in HCT116 cells by reducing CD44/24 ratio, causing G2/M phase arrest, and enhancing apoptosis.
Alper Durmaz   +6 more
wiley   +1 more source

A Facile Synthesis of 3‐Substituted Coumarins and Investigation of Their 3CLpro Inhibition Activity Against SARS‐CoV‐2

open access: yesChemistryOpen, EarlyView.
A user‐friendly protocol for the synthesis 3‐substituted coumarin derivatives was developed using Friedel‐Crafts alkylation and ozonolysis as key steps. Deactivation of 3‐chymotrypsin like protease (3CLpro) enzyme using these coumarin derivatives were investigated to explored their potential as 3CLpro inhibitors for Covid‐19 Therapeutics.
Manoj K. Choudhary   +5 more
wiley   +1 more source

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