Results 61 to 70 of about 95,816 (273)

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells [PDF]

Kosin Medical Journal, 2016
Objectives The aim of this study was whether quercetin induces cell death by caspase and MAPK signaling pathway in EGFR mutant lung cancer cells Methods PC-9 cells, EGFR mutant lung cancer cells, were treated various times and concentrations of quercetin
Eun Jin Lim, Jeunghoon Heo, Young-Ho Kim
doaj   +1 more source

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

Electrochemical Determination of Gallic Acid in Tea Samples Using Pyramidal Pt Nanoparticles

Advanced Electronic Materials, EarlyView.
A novel electrochemical sensor based on pyramidal Pt nanoparticles for gallic acid detection in black and green tea samples is developed. The sensor is prepared by a simple drop casting of nanoparticles on the electrode surface, without any supporting materials, such as polymer matrices and surfactants.
Tiziano Di Giulio, Maria Antonieta Ramírez‐Morales, Valentina Mastronardi, Giuseppe Mele, Rosaria Brescia, Pier Paolo Pompa, Cosimino Malitesta, Giuseppe Egidio De Benedetto, Mauro Moglianetti, Maria Ada Malvindi, Elisabetta Mazzotta   +10 more
wiley   +1 more source

Synthesis of ¹³¹I Labeled Quercetin through Oxidation Method Using Chloramine-T for Cancer Radiopharmaceuticals

Indonesian Journal of Chemistry, 2019
Quercetin is one of the flavonoid groups with antioxidant activity. The objective of this study was to achieve the labeled compound of 131I-quercetin as a radiotracer for diagnosis and cancer therapy with high labeling efficiency and radiochemical purity.
Maula Eka Sriyani, Dian Ayu Utami, Mega Susilo Dwike, Eva Maria Widyasari, Muharram Marzuki, Rizky Juwita Sugiharti, Witri Nuraeni   +6 more
doaj   +1 more source

Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease

Mediators of Inflammation, 2022
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder stemming from unrestrained immune activation and subsequent destruction of colon tissue.
Yong-Li Lyu, Hai-Feng Zhou, Jia Yang, Fa-Xi Wang, Fei Sun, Jun-Yi Li   +5 more
doaj   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Identification of bioactive compounds and molecular targets of Fuke Huahuang formulation to treat vaginitis

Animal Models and Experimental Medicine, EarlyView.
Fuke Huahuang formulation (FHF) is used to treat vaginitis, and it exerts a promising anti‐inflammatory effect in clinical use. However, the detailed components and mechanisms of FHF for treating vaginitis remain unreported, and further preclinical evaluation is required to reveal its potential pharmacological activities against vaginitis.
Huiyu Liu, Jie Mo, Cheng Liang, Qingting Chen, Bin Yang, Jiaqi Liu   +5 more
wiley   +1 more source

Greek Protected Designation of Origin Xinomavro Wines: A Deep Dive into Their Chemical Composition and Geographical Origin by Using Ultra High Performance Liquid Chromatography–Trapped Ion Mobility Spectrometry–Quadrupole Time of Flight–Mass Spectrometry

Analysis &Sensing, EarlyView.
Greek protected designation of origin Xinomavro wines are analyzed with ultra high performance liquid chromatography–trapped ion mobility spectrometry–quadrupole time of flight‐mass spectrometry (UHPLC‐TIMS‐QTOF‐MS). Both target and not‐target screening approaches are employed, leading to the identification and quantification of several polyphenols and
Panagiotis‐Loukas Gialouris, Eleni Nastou, Dafni Preza‐Mayo‐Kataki, Elli Goulioti, Yorgos Kotseridis, Nikolaos Thomaidis, Marilena Dasenaki   +6 more
wiley   +1 more source

The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds

Food Science &Nutrition, Volume 11, Issue 1, Page 39-56, January 2023., 2023
Rutin is a flavonoid present in many plant species. Because of its antioxidant, anti‐inflammatory, and anti‐apoptotic properties, rutin is of interest for its potential protective effects against toxic agents. Rutin has potential therapeutic effectiveness against several toxicants, and its beneficial effects are more than likely mediated by its ...
Sohrab Rahmani, Karim Naraki, Ali Roohbakhsh, A. Wallace Hayes, Gholamreza Karimi   +4 more
wiley   +1 more source