Results 91 to 100 of about 198,128 (343)

Conceptual Query Expansion [PDF]

open access: yes, 2004
Contains fulltext : 60245.pdf (Author’s version preprint ) (Open Access)
Grootjen, F.A., Weide, T.P. van der
openaire  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Semantic Sequential Query Expansion for Biomedical Article Search

open access: yesIEEE Access, 2018
The conventional sequential dependence model (SDM) has been proved to perform better than the bag of words model for biomedical article search because it pays attention to the sequence information within queries.
Fan Fang, Bo-Wen Zhang, Xu-Cheng Yin
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Using a Query Expansion Technique to Improve Document Retrieval [PDF]

open access: yes, 2008
Query expansion (QE) is a potentially useful technique to help searchers formulate improved query statements, and ultimately retrieve better search results. The objective of our query expansion technique is to find a suitable additional term. Two query
Abdelmgeid Amin, Aly
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

A Taxonomy and Survey of Semantic Approaches for Query Expansion

open access: yesIEEE Access, 2019
Conventional approaches to query expansion (QE) rely on the integration of an unstructured corpus and probabilistic rules for the extraction of candidate expansion terms.
Muhammad Ahsan Raza   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Knowledge-based Query Expansion in Real-Time Microblog Search

open access: yes, 2015
Since the length of microblog texts, such as tweets, is strictly limited to 140 characters, traditional Information Retrieval techniques suffer from the vocabulary mismatch problem severely and cannot yield good performance in the context of ...
Fan, Feifan   +3 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

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