Results 81 to 90 of about 37,968 (310)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Cloud Information Retrieval: Model Description and Scheme Design

open access: yesIEEE Access, 2018
The fast development of cloud technology has brought about a new trend in the field of information service: more and more information is being transferred to the cloud as requested.
Zhen Yang, Jiliang Tang, Huan Liu
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

An Improved Retrievability-Based Cluster-Resampling Approach for Pseudo Relevance Feedback

open access: yesComputers, 2016
Cluster-based pseudo-relevance feedback (PRF) is an effective approach for searching relevant documents for relevance feedback. Standard approach constructs clusters for PRF only on the basis of high similarity between retrieved documents.
Shariq Bashir
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

GO2PUB: Querying PubMed with semantic expansion of gene ontology terms [PDF]

open access: gold, 2012
Charles Bettembourg   +3 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Named Entity Recognition in Statistical Dataset Search Queries

open access: yesJurnal Nasional Teknik Elektro dan Teknologi Informasi
Search engines must understand user queries to provide relevant search results. Search engines can enhance their understanding of user intent by employing named entity recognition (NER) to identify the entity in the query.
Wildannissa Pinasti   +1 more
doaj   +1 more source

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