Results 41 to 50 of about 31,107 (259)

Novel Functional Materials via 3D Printing by Vat Photopolymerization

Advanced Functional Materials, EarlyView.
This Perspective systematically analyzes strategies for incorporating functionalities into 3D‐printed materials via Vat Photopolymerization (VP). It explores the spectrum of achievable functionalities in recently reported novel materials—such as conductive, energy‐storing, biodegradable, stimuli‐responsive, self‐healing, shape‐memory, biomaterials, and
Sergey S. Nechausov, Patrick Fesser, Boris A. Bulgakov, Ulrich S. Schubert   +3 more
wiley   +1 more source

Comparative efficacy of gambee and single interrupted suture patterns in reducing complications after canine enterotomy

Veterinary Evidence
PICO Question In dogs undergoing enterotomy, does using a Gambee suture pattern instead of a single interrupted suture pattern to close the intestinal incision reduce the risk of postoperative complications?
Anthi Anatolitou, Miltiadis Markou
doaj   +1 more source

EBM Tutorial: Formulating a Clinical Question (Out of Print)

MedEdPORTAL, 2007
Created and maintained by the Boston University Alumni Medical Library, this web-based tutorial designed for self-study can be completed in approximately 5 minutes and can be used to support evidence-based medicine (EBM) practice and curricular ...
Lauren Maggio, John Wiecha, Keven Jeffery, Mary Blanchard   +3 more
doaj   +1 more source

Integrating the Framing of Clinical Questions via PICO into the Retrieval of Medical Literature for Systematic Reviews [PDF]

Proceedings of the 2017 ACM on Conference on Information and Knowledge Management, 2017
The PICO process is a technique used in evidence based practice to frame and answer clinical questions. It involves structuring the question around four types of clinical information: Population, Intervention, Control or comparison and Outcome. The PICO framework is used extensively in the compilation of systematic reviews as the means of framing ...
Scells, Harrisen, Zuccon, Guido, Koopman, Bevan, Deacon, Anthony, Azzopardi, Leif, Geva, Shlomo   +5 more
openaire   +2 more sources

Ultra‐Thin Soft Pneumatic Actuation for Minimally Invasive Neural Interfacing

Advanced Materials Technologies, EarlyView.
Parylene C is a common polymer in bioelectronics, favored for its biological and chemical inertness. However, this makes bonding layers of Parylene C together very challenging. Here it is a laser to selectively weld layers of Parylene C to create high‐pressure fluidic actuation devices.
Lawrence Coles, Joe G. Troughton, Alejandro Carnicer‐Lombarte, George G. Malliaras, Christopher M. Proctor   +4 more
wiley   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Known-Item Retrieval Performance of a PICO-based Medical Question Answering Engine

Asia Pacific Journal of Information Systems, 2015
The performance of a novel medical question-answering engine called CliniCluster and existing search engines, such as CQA-1.0, Google, and Google Scholar, was evaluated using known-item searching. Known-item searching is a document that has been critically appraised to be highly relevant to a therapy question.
Vong, Wan-Tze, Then, Patrick Hang Hui
openaire   +2 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

The therapeutic effectiveness of oral cannabidiol in addition to current treatment in cats with osteoarthritis

Veterinary Evidence
Question In cats with osteoarthritis (OA), does the oral supplementation of cannabidiol (CBD) oil, compared to conventional treatment alone, improve treatment outcomes of reducing pain and improving locomotion?   Clinical bottom line The category
Oliver Wilkinson
doaj   +1 more source