Results 11 to 20 of about 3,014 (180)

Enhanced Sensitivity of a Modified Quaking-Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study. [PDF]

Ann Neurol
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Myskiw J, Fox R, Kielich DMS, Lamoureux L, Leonhardt M, Nykvist O, Slota JA, Avery K, Phillipson C, Frost K, Simon S, Appleby BS, Bailey-Elkin BA, Booth SA.   +13 more
europepmc   +2 more sources

Towards QUIC debuggability [PDF]

Proceedings of the Workshop on the Evolution, Performance, and Interoperability of QUIC, 2018
QUIC has been called the mother of all web protocols, as it deeply integrates aspects of TCP (reliability, flow control, congestion control, loss recovery), TLS (handshake, encryption keys) and HTTP/2 (streams, prioritization) together into one cross-layer implementation over UDP.
Robin Marx, Wim Lamotte, Jonas Reynders, Kevin Pittevils, Peter Quax   +4 more
openaire   +2 more sources

Evidence for different seeding activities of misfolded tau in classical and rapidly progressive Alzheimer's disease. [PDF]

Brain Pathol
The study analyzed the seeding activity of misfolded tau protein in Alzheimer's disease and rapidly progressive Alzheimer's disease patients and provides evidence for the existence of different tau assemblies supported by differences in cellular toxicity and morphology of thioflavin T‐positive real‐time quaking‐induced conversion products.
Schmitz M, Thüne K, Fischer AL, Hermann P, Cramm M, Kadel LS, Möbius W, Matschke J, Saleem T, Younas N, Zafar S, Altmeppen H, Glatzel M, Zerr I.   +13 more
europepmc   +2 more sources

And QUIC meets IoT: performance assessment of MQTT over QUIC [PDF]

2020 16th International Conference on Wireless and Mobile Computing, Networking and Communications (WiMob), 2020
We study the performance of the Message Queuing Telemetry Transport Protocol (MQTT) over QUIC. QUIC has been recently proposed as a new transport protocol, and it is gaining relevance at a very fast pace, favored by the support of key players, such as Google.
Fátima Fernández, Mihail Zverev, Pablo Garrido 0002, José R. Juárez, Josu Bilbao, Ramón Agüero   +5 more
openaire   +1 more source

Standardization of Data Analysis for RT-QuIC-Based Detection of Chronic Wasting Disease

Pathogens, 2023
Chronic wasting disease (CWD) is a disease affecting cervids and is caused by prions accumulating as pathogenic fibrils in lymphoid tissue and the central nervous system.
Gage R. Rowden, Catalina Picasso-Risso, Manci Li, Marc D. Schwabenlander, Tiffany M. Wolf, Peter A. Larsen   +5 more
doaj   +1 more source

QUIC-FEC: Bringing the benefits of forward erasure correction to QUIC [PDF]

2019 IFIP Networking Conference (IFIP Networking), 2019
Originally implemented by Google, QUIC gathers a growing interest by providing, on top of UDP, the same service as the classical TCP/TLS/HTTP/2 stack. The IETF will finalise the QUIC specification in 2019. A key feature of QUIC is that almost all its packets, including most of its headers, are fully encrypted.
Michel, François, De Coninck, Quentin, Bonaventure, Olivier   +2 more
openaire   +3 more sources

A field-deployable diagnostic assay for the visual detection of misfolded prions

Scientific Reports, 2022
Diagnostic tools for the detection of protein-misfolding diseases (i.e., proteopathies) are limited. Gold nanoparticles (AuNPs) facilitate sensitive diagnostic techniques via visual color change for the identification of a variety of targets. In parallel,
Peter R. Christenson, Manci Li, Gage Rowden, Marc D. Schwabenlander, Tiffany M. Wolf, Sang-Hyun Oh, Peter A. Larsen   +6 more
doaj   +1 more source

Pluginizing QUIC

Proceedings of the ACM Special Interest Group on Data Communication, 2019
Application requirements evolve over time and the underlying protocols need to adapt. Most transport protocols evolve by negotiating protocol extensions during the handshake. Experience with TCP shows that this leads to delays of several years or more to widely deploy standardized extensions.
De Coninck, Quentin, Michel, François, Piraux, Maxime, Rochet, Florentin, Given-Wilson, Thomas, Legay, Axel, Pereira, Olivier, Bonaventure, Olivier   +7 more
openaire   +1 more source

Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies

Acta Neuropathologica Communications, 2021
Definitive diagnosis of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) relies on postmortem finding of disease-associated alpha-synuclein (αSynD) as misfolded protein aggregates in the central nervous system (CNS). The recent development of
Connor Bargar, Wen Wang, Steven A. Gunzler, Alexandra LeFevre, Zerui Wang, Alan J. Lerner, Neena Singh, Curtis Tatsuoka, Brian Appleby, Xiongwei Zhu, Rong Xu, Vahram Haroutunian, Wen-Quan Zou, Jiyan Ma, Shu G. Chen   +14 more
doaj   +1 more source

Implementation and analysis of QUIC for MQTT [PDF]

Computer Networks, 2019
Transport and security protocols are essential to ensure reliable and secure communication between two parties. For IoT applications, these protocols must be lightweight, since IoT devices are usually resource constrained. Unfortunately, the existing transport and security protocols -- namely TCP/TLS and UDP/DTLS -- fall short in terms of connection ...
Puneet Kumar 0004, Behnam Dezfouli
openaire   +2 more sources