Results 51 to 60 of about 429,936 (298)

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

Chromospheric Spectra of Small-scale Dynamic Features Observed on and off Solar Disk with Goode Solar Telescope

open access: yesThe Astrophysical Journal
Our study of H α line profiles of rapid blue- and redshifted excursions measured with Goode Solar Telescope revealed an asymmetrical three-peak structure present in the blue wing of the H α line, suggesting complex internal velocity fields that may ...
Vasyl Yurchyshyn   +6 more
doaj   +1 more source

Modulation of Cosmic-Ray Antiprotons in the Heliosphere: Simulations for a Solar Cycle

open access: yesThe Astrophysical Journal, 2023
The precision measurements of galactic cosmic-ray protons from the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics and the Alpha Magnetic Spectrometer are reproduced using a well-established three-dimensional numerical model for ...
O. P. M. Aslam   +3 more
doaj   +1 more source

Inferring depth-dependent plasma motions from surface observations using the DeepVel neural network

open access: yesJournal of Space Weather and Space Climate, 2021
Coverage of plasma motions is limited to the line-of-sight component at the Sun’s surface. Multiple tracking and inversion methods were developed to infer the transverse motions from observational data.
Tremblay Benoit   +4 more
doaj   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

open access: yesAdvanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun   +5 more
wiley   +1 more source

Magnetic Topology and Loop Statistics in Observed Coronal Holes Using Potential Field Modeling

open access: yesThe Astrophysical Journal
Potential field source surface (PFSS) models are widely used to study the solar corona and form the basis for solar wind forecasting, yet they often fail to reproduce observed properties of coronal holes.
Stephan G. Heinemann   +2 more
doaj   +1 more source

Cosmogenic radionuclides reveal an extreme solar particle storm near a solar minimum 9125 years BP

open access: yesNature Communications, 2022
Cosmogenic radionuclides from ice cores and tree rings indicate that an extreme solar proton event has hit Earth about 9200 years ago. Contrary to expectations, the event occurred during a quiet phase of the Sun within the 11 year solar cycle.
Chiara I. Paleari   +12 more
doaj   +1 more source

Iqsy solar eclipse, scientific expedition [PDF]

open access: yes, 1965
Solar eclipse scientific observation program for International Quiet Sun Year ...

core   +1 more source

A Single‐Enzyme Activated CRISPR‐Cas12a Nano System via Subtly Balanced dsDNA for Kinetic‐Gated UDG Detection and Spatiotemporal Cellular Imaging

open access: yesAdvanced Science, EarlyView.
Kinetic‐gated CRISPR–Cas12a activation enables single‐enzyme detection and spatiotemporal imaging of UDG ABSTRACT Uracil‐DNA glycosylase (UDG) is a key enzyme in base excision repair and an important biomarker for genomic stability and disease. In many reported sensing systems, uracil excision is coupled to signal generation through additional ...
Kejun Dong   +12 more
wiley   +1 more source

Ultrasound Activated Piezoelectric Dural Patches to Drive Endogenous Neural Stem Cell–Mediated Repair Traumatic Brain Injury

open access: yesAdvanced Science, EarlyView.
This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou   +7 more
wiley   +1 more source

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