Results 121 to 130 of about 24,434,811 (177)

Synthesis and Antioxidant Properties of Novel Quinazoline Derivatives

Quinazoline derivatives have expressed a broad spectrum of biological activities, but there are few examples in literature on an antioxidant activity of different quinazolines. On the basis of literature by Chinese scientists on the effective antioxidant
Tetere, Zenta, Zicāne, Daina, Rāviņa, Irisa, Rijkure, Inese, Mieriņa, Inese   +4 more
core  

Ambient and selective synthesis of dihydro-benzimidazoquinazolines in deep eutectic melt of betaine and trichloroacetic acid. [PDF]

RSC Adv
Fadaei Z, Rad-Moghadam K, Pakravan P.
europepmc   +1 more source

Alkaloids as Emerging Neuroprotective Agents for Neurodegenerative Disorders: Insights into Tryptanthrin and Its Derivatives. [PDF]

Int J Mol Sci
Khan A, Khan H, Park IH, Aldahmash BA, Khan MS, Yang G, Kang KS.   +6 more
europepmc   +1 more source

Generative AI-Based Drug Design: Target-Aware Molecular Generation for EGFR Type I Inhibitors with Multiplatform Docking Validation. [PDF]

ACS Omega
Khan T, Kwak YB, Kim HC.
europepmc   +1 more source

Design, Synthesis, and Biological Activity Evaluation of Quinazoline-Based PLK4 Inhibitors. [PDF]

Biomedicines
Sun W, Qi Z, Hu N, Liu N, Mu S, Zhang H, Gao Z, Luo Z, Sun Y, Zhao D, Cheng M.   +10 more
europepmc   +1 more source

From Fragment Hit to Clinical Candidate: Discovery of Dual H1R/H4R Ligands with Superior Efficacy in Allergic Conjunctivitis. [PDF]

J Med Chem
Weber P, Smits R, Lim HD, Andaloussi M, Wijkmans J, de Boer B, Tran TD, Zarzycka B, Dekker ME, van der Meer T, Riemens R, Hauwert N, Wagner G, Vischer HF, Chapin MJ, Gomes P, Whitlock A, Wijtmans M, Leurs R, de Esch IJP.   +19 more
europepmc   +1 more source

Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST. [PDF]

Nat Commun
Schulz T, Beerbaum M, Scrima A, Jantzen H, Teuber A, Mühlenberg T, Ebel L, Garcia-Fossa F, George A, Berner N, Weisner J, Müller MP, Wilhelm S, Sievers S, Bauer S, Rauh D.   +15 more
europepmc   +1 more source

Identification of new Trypanosoma cruzi-specific protein synthesis inhibitors by using a developed high-throughput in vitro translation assay. [PDF]

Int J Parasitol Drugs Drug Resist
Mantovani CC, Freitas FRN, Moraes CB, Dos Santos GRR, Cruz LR, Kratz JM, Aktas BH, Schenkman S.   +7 more
europepmc   +1 more source

One-Pot Gateway to Quinazoline-Thiohydantoin Fused Scaffolds and Discovery of Their Antileukemic Activity. [PDF]

JACS Au
Kersting L, Zippel C, Herrmann L, Elbadawi M, Seo EJ, Heckmann F, Saeed MEM, Gaube A, Tailor D, Dheeraj A, Malhotra SV, Muehlich S, Efferth T, Tsogoeva SB.   +13 more
europepmc   +1 more source

New Alkaloids from the Hydrothermal Vent-Derived Fungus <i>Aspergillus clavatus</i> C2WU and Their Mitochondrial Protective and Anti-Photoaging Effects. [PDF]

Mar Drugs
Pan J, Zhou C, Wei J, Simeunovic D, Yan W, Yin Q, Zou M, Wu X, Feng Z, Zhang M, Huang H, Wu B.   +11 more
europepmc   +1 more source