Results 151 to 160 of about 24,434,811 (177)

Design, Synthesis of Novel Quinazolinone Derivatives and Evaluation of EGFR Kinase Inhibition Activity via In Vitro and In Silico Studies. [PDF]

Chem Biol Drug Des
Kaya AZ, Evren AE, Akalın-Çiftçi G, Yurttaş L.   +3 more
europepmc   +1 more source

Discovery of Small-Molecule Antagonists of PHF1 and 19 Demonstrates the Ligandability of PRC2 Accessory Proteins. [PDF]

ACS Bio Med Chem Au
Amick IE, Johnson RL, Liu J, Bussey-Sutton CR, Mancera-Ortiz IY, Norris-Drouin JL, Boyd SR, Cholensky SH, Spangler CJ, McGinty RK, Strahl BD, Kutateladze TG, Frye SV, James LI.   +13 more
europepmc   +1 more source

Chemical Scaffolds Driving Modern Anticancer Drug Discovery and Radiotheranostics: Structural Determinants, Translational Opportunities and Future Perspectives. [PDF]

Pharmaceuticals (Basel)
Rusek M.
europepmc   +1 more source

Novel 5-Aryl-[1,2,4]triazoloquinazoline Fluorophores: Synthesis, Comparative Studies of the Optical Properties and ICT-Based Sensing Application. [PDF]

Molecules
Kopotilova AE, Permyakova JV, Starnovskaya ES, Moshkina TN, Novikov AS, Slepukhin PA, Nosova EV.   +6 more
europepmc   +1 more source

Virtual Screening, Synthesis and In Vitro Characterization of Histamine H₄ Receptor Ligands Based on Pyrimidine Scaffolds. [PDF]

Int J Mol Sci
Michalak O, Cybulski M, Krzeczyński P, Zegrocka-Stendel O, Dutkiewicz M, Dymkowska D, Olejarz-Maciej A, Karcz T, Dubiel M, Mehta P, Kubiszewski M, Lorkowski M, Jakowiecki J, Pasznik P, Miszta P, Stark H, Koziak K, Filipek S.   +17 more
europepmc   +1 more source

Recent Developments and Structure-Activity Relationships of BRAF Inhibitors for Cancer Drug Discovery. [PDF]

Arch Pharm (Weinheim)
Guo XK, Rakesh KP, Raju S, Sharath Kumar KS, Qin HL.   +4 more
europepmc   +1 more source

Gallium/Indium-Promoted [4 + 2] Annulation of 2‑Aminobenzonitriles with Alkynes and Dimerization of 2‑Aminobenzonitriles: One-Pot Access to 4‑Aminoquinolines and 4‑Amino-2-Arylquinazolines. [PDF]

ACS Omega
Sakai N, Ishii M, Yamauchi S, Ogiwara Y, Ishida K.   +4 more
europepmc   +1 more source

Addition of alkyllithiums to 3H-quinazoline-4-thione and various substituted quinazoline derivatives; application in synthesis [PDF]

Journal of Sulfur Chemistry, 2005
Reaction of 3H-quinazoline-4-thione (1) with two mole equivalents of an alkyllithium (t-BuLi, n-BuLi or MeLi) at−78 °C in dry THF gave the corresponding 2-alkyl-1,2-dihydro-3H-quinazoline-4-thione (4, 5 or 6) in high yield.
El-Hiti Ga, Keith Smith, Amany S Hegazy   +2 more
exaly   +2 more sources

Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids

Molecules, 2016
By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2–21 were synthesized using a simple and convenient method.
Marwa El-Gazzar, Parvez Mk, Mostafa Ghorab   +2 more
exaly   +2 more sources

Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives

Results in Chemistry
The rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures.
Hanamant B. Sannakki, Dharyappa Teli, Vishwanath Halappanavar, Sangappa Teli   +3 more
exaly   +2 more sources