Results 131 to 140 of about 6,888 (163)

5-Substituted quinazoline antifolates

European Journal of Cancer (1965), 1980
Abstract Two new 5 -substituted- 2 -amino- 4 -hydroxy-quinazoline antifolates are described. The presence of the 5 -substituent reduced the inhibitory effect upon thymidylate synthetase. In contrast, the 2,4 -diaminoquinazoline series, the same 5 -substituents improved the inhibition.
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Quinazoline derivatives with antitubercular activity

Il Farmaco, 2000
4-Quinazolinol was prepared by the reaction of anthranilic acid and formamide. The hydroxy group was converted into the thiol function by treatment with phosphorus(V)sulfide, and the subsequent alkylation of the thiol group was carried out with alkylhalides under the conditions of phase-transfer catalysis.
J, Kunes, J, Bazant, M, Pour, K, Waisser, M, Slosárek, J, Janota   +5 more
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Synthesis of Quinazolinones and Quinazolines

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
David J. Connolly, Declan Cusack, Timothy P. O'Sullivan, Patrick J. Guiry   +3 more
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Quinazolines. VIII. Synthesis of 1,3‐diaminobenzo[f]quinazolines

Journal of Heterocyclic Chemistry, 1972
AbstractTwenty‐one 1,3‐diaminobenzo[f]quinazolines (2, R = H, alkyl, halogen, methoxy) were synthesized as planar tricyclic analogs of the antimalarial agent pyrimethamine (1). The synthetic methods included i) condensation of 1‐cyano‐2‐naphthylamines with cyanamide in the presence of pyridine hydrochloride, ii) cyclization of N1,N5‐bis(2‐naphthyl ...
Andre Rosowsky, Katherine K. N. Chen, Marilyn E. Nadel, Nicholas Papathanasopoulos, Edward J. Modest   +4 more
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ChemInform Abstract: Synthesis of New Chromeno[4,3,2‐de]quinazolin‐2‐ones, ‐quinazolines and ‐pyrrolo[2,1‐b]quinazolines

ChemInform, 2008
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Carlos M. Martinez‐Viturro, Domingo Dominguez   +1 more
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QUINAZOLINE COMPOUNDS

2015
The present invention relates to quinazoline compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, R3, R4, R5, R6 and R7 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical ...
Goldberg,, Kristin, Hamilton,, Niall, Jones,, Stuart, Jordan,, Allan, Lyons,, Amanda, Newton,, Rebecca, Ogilvie,, Donald, Waszkowycz,, Bohdan   +7 more
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4,5-Dihydropyrazolo[3,4-f]quinazolines

Chemistry of Heterocyclic Compounds, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
N. N. Tonkikh, K. V. Ryzhanova, M. V. Petrova, A. Strakovs   +3 more
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Polarography of Quinazoline

Nature, 1964
THE polarographic behaviour of quinazoline displays special features which are not shown by the related compounds quinoxaline, phthalazine and 1,5-naphthyridine.
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Quinazolines. Part X. The fragmentation of quinazolines under electron impact

Journal of the Chemical Society B: Physical Organic, 1967
Quinazoline, under electron impact, fragments by the consecutive loss of two molecules of HCN to give a benzyne radical ion. Fragmentation of substituted quinazolines also occurs by this pathway as well as by others normally associated with the breakdown of the substituent.
T. J. Batterham, A. C. K. Triffett, J. A. Wunderlich   +2 more
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Quinazolines

Chemistry of Heterocyclic Compounds, 1976
Kh. M. Shakhidoyatov, A. Irisbaev, L. M. Yun, �. Oripov, Ch. Sh. Kadyrov   +4 more
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