Results 131 to 140 of about 7,050 (179)

Biology of quinoline and quinazoline alkaloids

2022
Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted scientific and popular interest worldwide since the 19th century. More than 600 compounds have been isolated from nature to date. To build on our two prior reviews, we reexamined the promising molecules described in previous reports and provided
Xiao-Fei, Shang, Susan L, Morris-Natschke, Ying-Qian, Liu, Xiu-Hui, Li, Ji-Yu, Zhang, Kuo-Hsiung, Lee   +5 more
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Quinazoline analogues of folic acid

Journal of the Chemical Society C: Organic, 1970
Analogues of folic acid having the pteridine ring replaced by quinazoline have been prepared by reductive condensation of appropriately substituted quinazoline-6-carbaldehydes and -carbonitriles with diesters of N-(p-aminobenzoyl) amino-acids, followed by hydrolysis.
J, Davoll, A M, Johnson
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Quinazolines. Part VIII. Electronic effects in 2-substituted quinazolines

Journal of the Chemical Society C: Organic, 1966
In a study of the cations of twenty 2-substituted quinazolines, it was found that covalent hydration of the 3,4-double bond decreased according to the electronic effect of the 2-substituent; viz, +l > +M > –l. This is explained by the effect of the substituent on the polarity of the C-4, N-3 double bond. The effect of the acyl group on the rate of ring
W. L. F. Armarego, J. I. C. Smith
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Quinazolines as Inhibitors of Xanthe Oxidase

Journal of Pharmaceutical Sciences, 1974
A series of 23 quinazolines and 5,6,7,8-tetrahydroquinazolines was evaluated for inhibition of bovine milk xanthine oxidase. The synthesis of four of these compounds has not been reported previously. Several 2-amino-4-hydroxyquinazolines, as well as 2-amino-4-mercaptoquinazoline, were effective inhibitors of this enzyme.
D G, Priest, J B, Hynes, C W, Jones, W T, Ashton   +3 more
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Polarography of Quinazoline

Nature, 1964
THE polarographic behaviour of quinazoline displays special features which are not shown by the related compounds quinoxaline, phthalazine and 1,5-naphthyridine.
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Quinazolines. Part X. The fragmentation of quinazolines under electron impact

Journal of the Chemical Society B: Physical Organic, 1967
Quinazoline, under electron impact, fragments by the consecutive loss of two molecules of HCN to give a benzyne radical ion. Fragmentation of substituted quinazolines also occurs by this pathway as well as by others normally associated with the breakdown of the substituent.
T. J. Batterham, A. C. K. Triffett, J. A. Wunderlich   +2 more
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Synthesis of Unsymmetrical Dialkoxy Quinazolines.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Matthieu Desroses, Guillaume Laconde, Patrick Depreux, Jean-Pierre Hénichart   +3 more
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Quinazoline studies. Part XII. Action of acid and alkali on quinazoline

Journal of the Chemical Society C: Organic, 1968
Quinazoline was converted into 2-aminobenzaldehyde and its anhydro-polymers (the trimer, the tetramer, and the monoformyl-tetramer) by the action of hot dilute acid or alkali. The substance of high-molecular weight formed from quinazoline below pH 1·5 was found to be a polymer of the 3,4-adduct of the latter with 2-aminobenzaldehyde.
Adrien Albert, Hiroshi Yamamoto
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5-Substituted quinazoline antifolates

European Journal of Cancer (1965), 1980
Abstract Two new 5 -substituted- 2 -amino- 4 -hydroxy-quinazoline antifolates are described. The presence of the 5 -substituent reduced the inhibitory effect upon thymidylate synthetase. In contrast, the 2,4 -diaminoquinazoline series, the same 5 -substituents improved the inhibition.
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Quinazoline Yellow SS in cosmetics

Contact Dermatitis, 1976
Five cases of allergic contact dermatitis from Quinazoline Yellow SS (D and C Yellow 11) in cosmetics are described, three from a lipstick and two from a rouge stick. Four of them showed marked oedema spreading to the eyelids and down to the neck. Two of them required systemic steroids.
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