Results 11 to 20 of about 4,652 (165)

Intramolecular Hydrogen Bonds in Conformers of Quinine and Quinidine: An HF, MP2 and DFT Study

Molecules, 2017
Quinine is an alkaloid with powerful antimalarial activity, isolated from the bark of Peru’s cinchona trees. Quinidine is an erythro diastereoisomer of quinine also exhibiting antimalarial activity.
Mireille K. Bilonda, Liliana Mammino
doaj   +1 more source

Physiologically‐based pharmacokinetic modeling for primary metabolites of CYP3A and P‐glycoprotein inhibitors in drug–drug interactions: Should we assume the free drug hypothesis?

, 2023
CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 8-12, January 2023.
Shinji Yamazaki, Raymond Evers, Loeckie De Zwart   +2 more
wiley   +1 more source

Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model

Frontiers in Pharmacology, 2019
The cardiac Nav1.5 mediated sodium current (INa) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluation ...
Dieter V. Van de Sande, Ivan Kopljar, Ivan Kopljar, Ard Teisman, David J. Gallacher, Dirk J. Snyders, Hua Rong Lu, Alain J. Labro   +7 more
doaj   +1 more source

Two South Indian children with KCNT1-related malignant migrating focal seizures of infancy – Clinical characteristics and outcome of targeted treatment with quinidine

Annals of Indian Academy of Neurology, 2019
KCNT1 gene encodes a sodium-gated potassium channel subunit that plays an important role in regulating excitability in neurons. Quinidine is a partial antagonist of this channel.
Abhijit Anil Patil, K P Vinayan, Arun Grace Roy   +2 more
doaj   +1 more source

Involvement of Multidrug Resistance Modulators in the Regulation of the Mitochondrial Permeability Transition Pore

Membranes, 2022
The permeability transition pore in mitochondria (MPTP) and the ATP-binding cassette transporters (АВС transporters) in cell membranes provide the efflux of low-molecular compounds across mitochondrial and cell membranes, respectively.
Tatiana Fedotcheva, Nikolai Shimanovsky, Nadezhda Fedotcheva   +2 more
doaj   +1 more source

Electrical storm in an acquired short QT syndrome successfully treated with quinidine

Clinical Case Reports, 2019
Short QT syndrome (SQTS) is a malignant heart disorder defined by the presence of ventricular arrhythmias causing syncope and sudden cardiac arrest. The prevalence in the pediatric population is 0.05%.
Michael Spartalis, Efthimios Livanis, Eleftherios Spartalis, Alexandros Tsoutsinos   +3 more
doaj   +1 more source

Therapeutic Drug Monitoring of Quinidine in Pediatric Patients with KCNT1 Genetic Variants

Pharmaceutics, 2022
Quinidine (QND) is an old antimalarial drug that was used in the early 20th century as an antiarrhythmic agent. Currently, QND is receiving attention for its use in epilepsy of infancy with migrating focal seizures (EIMFS) due to potassium sodium ...
Alessandro Ferretti, Raffaele Simeoli, Sara Cairoli, Nicola Pietrafusa, Marina Trivisano, Carlo Dionisi Vici, Nicola Specchio, Bianca Maria Goffredo   +7 more
doaj   +1 more source

In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.

PLoS ONE, 2017
AimsShort QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr)
Cunjin Luo, Kuanquan Wang, Henggui Zhang
doaj   +1 more source

Discussion on the Action of Quinidine in Cases of Cardiac Disease [PDF]

, 1923
A. E. Clark-Kennedy
  +7 more sources

Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics

Frontiers in Veterinary Science
IntroductionQuinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects.
Taisuke Kuroda, Yohei Minamijima, Christopher Ken Kinman, Yuji Takahashi, Yusaku Ebisuda, Kaori Inoue, Hiroshi Ishikawa, Hiroshi Mita, Norihisa Tamura, Toshio Nukada, Pierre-Louis Toutain, Pierre-Louis Toutain, Minoru Ohta   +12 more
doaj   +1 more source