Results 11 to 20 of about 38,165 (238)
Response to Tutorial Drug-Drug Interactions by EM Sellers. [PDF]
Clin Transl SciClinical and Translational Science, Volume 19, Issue 3, March 2026.
Das JL, Ajavon-Hartmann AT, Schmith VGD.
europepmc +2 more sources
Precision therapy with quinidine of KCNT1‐related epileptic disorders: A systematic review
British Journal of Clinical Pharmacology, 2022 Despite numerous studies on quinidine therapies for epilepsies associated with KCNT1 gene mutations, there is no consensus on its clinical utility. Thus, we reviewed studies evaluating the efficacy and safety of quinidine in KCNT1‐related epileptic ...
Daokun Xu +5 more
semanticscholar +1 more source
Quinidine in the Management of Recurrent Ventricular Arrhythmias: A Reappraisal.
JACC Clinical Electrophysiology, 2021 OBJECTIVE This study aimed to review the utility of quinidine in patients presenting with recurrent sustained ventricular arrhythmia (VA) and limited antiarrhythmic drug (AAD) options.
D. Li +9 more
semanticscholar +1 more source
Cardiocerebral channelopathy caused by KCND3 mutation in a child: A case report
Frontiers in Pediatrics, 2022 Early repolarization syndrome is rare in children. Mutation of genes encoding ion channels could display mixed electrophysiological phenotype of Kv4.3 including both cardiac phenotype (early repolarization syndrome, atrial fibrillation) and cerebral ...
Yi Zhang, He Jiang, Xiao-mei Li
doaj +1 more source
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]
, 2002 Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Bromley, Elizabeth V +5 more
core +4 more sources
A case report of pitfall of fever and altered mental status: cerebral malaria due to in an adult traveler returning from Congo [PDF]
Journal of Neurocritical Care, 2023 Background Cerebral malaria, caused by Plasmodium falciparum, can lead to severe neurological complications. It is more frequently observed in children than in adults.
Soo-Hyun Park +4 more
doaj +1 more source
Brain Research Bulletin, 2020 During the last decades several new drug formulations were developed to target the central nervous system (CNS) from the nasal cavity. However, in these studies less attention was paid to the possible drug-drug interactions in case of multi-drug therapy.
L. Bors +7 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Case introduction: In this work we present a female infant patient with epilepsy of infancy with migrating focal seizures (EIMFS). Although many pharmacological schemes were attempted, she developed an encephalopathy with poor response to antiepileptic ...
M. C. Kravetz +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K). Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient ...
Mengying Huang +23 more
doaj +1 more source
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]
, 2016 Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia +17 more
core +1 more source