Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics [PDF]
Frontiers in Veterinary ScienceIntroductionQuinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects.
Taisuke Kuroda +12 more
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Electrical Storms in Brugada Syndrome: Review of Pharmacologic and Ablative Therapeutic Options [PDF]
Indian Pacing and Electrophysiology Journal, 2005 Electrical storm occurring in a patient with the Brugada syndrome is an exceptional but malignant and potentially lethal event. Efficient therapeutic solutions should be known and urgently applied because of the inability of usual antiarrhythmic means in
Maury P, Hocini M, Haïssaguerre M
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Exploring the Role of the KCNK1 Potassium Channel and Its Inhibition Using Quinidine in Treating Head and Neck Squamous Cell Carcinoma [PDF]
Clinical and Experimental OtorhinolaryngologyObjectives. Our study aimed to explore the role of the potassium channel KCNK1 in head and neck squamous cell carcinoma, focusing on its impact on tumor growth, invasion, and metastasis.
Hyun Woo Baek, Eunjung Han, Kyoung Ho Oh
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Comparison between Inhibition of CatSper and KSper Channels with NNC 55-0396 and Quinidine on Human Sperm Function [PDF]
Iranian Journal of Medical SciencesBackground: Calcium enters human sperm through the “Cation Channel of Sperm” (CatSper), while potassium ions exit via the sperm potassium channel (KSper).
Ali Asghar Zarei +4 more
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SYNTHETIC SUBSTITUTES FOR QUINIDINE [PDF]
British Journal of Pharmacology and Chemotherapy, 1946 G. S. Dawes
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Quinidine for Brugada syndrome: Panacea or poison? [PDF]
HeartRhythm Case Reports, 2016 published_or_final_versio
Jo-Jo Hai, MBBS +5 more
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A phase I drug–drug interaction study to assess the effect of futibatinib on P‐gp and BCRP substrates and of P‐gp inhibition on the pharmacokinetics of futibatinib [PDF]
Clinical and Translational ScienceFutibatinib, an inhibitor of fibroblast growth factor receptor 1–4, is approved for the treatment of patients with advanced cholangiocarcinoma with FGFR2 fusions/rearrangements. In this phase I drug–drug interaction study, the effects of futibatinib on P‐
Amanda Long +7 more
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Frontiers in Neurology, 2022 AimTo evaluate the efficacy of anti-seizure medications (ASMs), quinidine, and ketogenic diet therapy (KDT) for KCNT1-related epilepsy and to explore genotype-efficacy correlations.MethodsWe collected the data for KCNT1-related epilepsy cases from our ...
Zehong Lin +30 more
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Cardiocerebral channelopathy caused by KCND3 mutation in a child: A case report
Frontiers in Pediatrics, 2022 Early repolarization syndrome is rare in children. Mutation of genes encoding ion channels could display mixed electrophysiological phenotype of Kv4.3 including both cardiac phenotype (early repolarization syndrome, atrial fibrillation) and cerebral ...
Yi Zhang, He Jiang, Xiao-mei Li
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Frontiers in Pharmacology, 2021 Case introduction: In this work we present a female infant patient with epilepsy of infancy with migrating focal seizures (EIMFS). Although many pharmacological schemes were attempted, she developed an encephalopathy with poor response to antiepileptic ...
M. C. Kravetz +6 more
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