Results 11 to 20 of about 4,432 (113)
The Journal of Clinical Pharmacology, EarlyView.Abstract To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double‐blind, randomized, placebo‐controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge test after administering placebo, DEX, or DOR.
Saeed Rezaee +3 more
wiley +1 more source
Evaluation of propranolol and quinidine in the treatment of quinidine-resistant arrhythmias [PDF]
The American Journal of Cardiology, 1971 Abstract Combining propranolol and quinidine should improve the antiarrhythmic action of quinidine by blocking beta adrenergic receptors, an action helpful in cases of arrhythmias associated with anesthetic agents, digitalis and stress. To test this hypothesis, 60 patients with paroxysmal arrhythmias resistant to quinidine and 17 with chronic atrial ...
Fors, Jr. , William J. +2 more
openaire +4 more sources
Pest Management Science, EarlyView.Trends in semiochemical research highlight promising attractants and repellents for ‘push–pull’ pest control strategies of the grey field slug. Extracts from plants, predators, entomopathogenic fungi, and essential oils demonstrate potential in modifying grey field slug behaviour, inducing avoidance, antifeeding responses, or mortality, offering ...
Suleiman Mustapha +5 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal +6 more
wiley +1 more source
Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger +4 more
wiley +1 more source
Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient
The Journal of Physiology, EarlyView.Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo +5 more
wiley +1 more source
Journal of the Science of Food and Agriculture, Volume 105, Issue 12, Page 6850-6861, September 2025.Abstract BACKGROUND The present study aimed to measure bioavailability (BA) indicators, including epithelial barrier function, apparent permeability (Papp) and efflux ratio, of 84 types of phytochemicals using Caco‐2 cell and to develop predictive model systems using machine learning with a quantitative structure–property relationship (QSPR) model ...
Kang‐Woo Lee +9 more
wiley +1 more source
Muscle &Nerve, Volume 72, Issue 3, Page 455-463, September 2025.ABSTRACT Introduction/Aims Little is known about the state of palliative care (PC) for people with ALS (pALS) in the U.S. We aimed to examine current practice regarding PC for pALS and how it can be improved. Methods ALS and PC clinicians completed surveys about: (1) strengths and limitations of PC for pALS provided by ALS and PC teams, (2) reasons for
Kara E. Bischoff +9 more
wiley +1 more source
Independent derivations of the axis of arrhythmia for predicting drug‐induced torsades de pointes
British Journal of Pharmacology, Volume 182, Issue 18, Page 4299-4313, September 2025.Abstract Background and Purpose: Torsades de pointes is a potentially lethal ventricular arrhythmia that can be induced by many classes of drugs. The risk for a given drug depends upon the combination of cardiac ion channels that it targets. The axis of arrhythmia quantifies that risk. It is a conceptual line in the electrophysiology that describes the
Stewart Heitmann +2 more
wiley +1 more source