Results 41 to 50 of about 16,625 (226)

Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade and guides anti-seizure strategy development

eLife
Quinidine has been used as an anticonvulsant to treat patients with KCNT1-related epilepsy by targeting gain-of-function KCNT1 pathogenic mutant variants.
Tian Yuan, Yifan Wang, Yuchen Jin, Hui Yang, Shuai Xu, Heng Zhang, Qian Chen, Na Li, Xinyue Ma, Huifang Song, Chao Peng, Ze Geng, Jie Dong, Guifang Duan, Qi Sun, Yang Yang, Fan Yang, Zhuo Huang   +17 more
doaj   +1 more source

Supratherapeutic drug concentration triggers: A novel data‐driven approach to assess their value for medication safety surveillance in intensive care

British Journal of Clinical Pharmacology, EarlyView.
Aims Electronic triggers (e‐triggers) are used as screening signals to detect potential adverse drug events (ADEs) and offer an effective system level approach for medication safety surveillance. Their clinical utility is typically evaluated through time‐consuming manual chart review by experts, limiting implementation.
Anne Paulien Langermans, Izak A. R. Yasrebi‐de Kom, Dylan Wayne de Lange, Nicolette Fransisca de Keizer, Joanna E. Klopotowska, on behalf of the RESCUE Study group, C. S. C. Bouman, E. N. van Roon, P. F. Schutte, J. ten Cate, D. van Balen, S. Hendriks, C. Lau, W. J. Vermeijden, A. Beishuizen, J. B. Masselink, P. E. Spronk, H. J. M. van Kan, P. W. de Feiter, E. J. Wils, A. Wieringa, A. J. Valkenburg, W. M. van den Bergh, M. H. Renes, W. Bult, E. de Jonge, M. Hoeksema, E. J. Wesselink, I. M. Purmer, B. E. Bosma, S. H. W. van Bree, H. J. W. Lammers, R. J. Bosman, E. J. F. Franssen, A. Karakus, M. Sigtermans, E. M. Kuck, D. A. Dongelmans, M. J. H. Aries, E. V. Uijtendaal, M. C. Reuland   +40 more
wiley   +1 more source

Incidence, recurrence and management of electrical storm in Brugada syndrome

Frontiers in Cardiovascular Medicine, 2022
BackgroundBrugada syndrome (BrS) is associated with ventricular tachyarrhythmias. However, the presence of electrical strom (ES) and its management still debated.ObjectivesWe present the outcome and management of 44 BrS patients suffering from ES ...
Ibrahim El-Battrawy, Ibrahim El-Battrawy, Ibrahim El-Battrawy, Gretje Roterberg, Jacqueline Kowitz, Assem Aweimer, Siegfried Lang, Siegfried Lang, Andreas Mügge, Xiaobo Zhou, Xiaobo Zhou, Ibrahim Akin, Ibrahim Akin   +12 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Increased quinidine plasma concentrations during administration of verapamil: A new quinidine-verapamil interaction

, 1986
A number of drug interactions that involve quinidine have been reported. 1 These include both pharmacokinetic interactions in which plasma concentrations of other drugs, most notably digoxin, are influenced by quinidine, and pharmacologic interactions ...
Estes, Daneil M, Kessler, Kenneth M, Castellanos, Agustin, Palomo, Andres R, Trohman, Richard G, Myerburg, Robert J   +5 more
core   +1 more source

In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.

PLoS ONE, 2017
AimsShort QT syndrome (SQTS) is an inherited disorder associated with abnormally abbreviated QT intervals and an increased incidence of atrial and ventricular arrhythmias. SQT1 variant (linked to the rapid delayed rectifier potassium channel current, IKr)
Cunjin Luo, Kuanquan Wang, Henggui Zhang
doaj   +1 more source

A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. [PDF]

PLoS Genetics, 2014
The emerging resistance to quinine jeopardizes the efficacy of a drug that has been used in the treatment of malaria for several centuries. To identify factors contributing to differential quinine responses in the human malaria parasite Plasmodium ...
Cecilia P Sanchez, Chia-Hao Liu, Sybille Mayer, Astutiati Nurhasanah, Marek Cyrklaff, Jianbing Mu, Michael T Ferdig, Wilfred D Stein, Michael Lanzer   +8 more
doaj   +1 more source

Quinidine photosensitivity.

Archives of dermatology, 1985
A 55-year-old woman developed a dermatitis confined to light-exposed areas while taking quinidine gluconate, warfarin sodium, furosemide, spironolactone, and digoxin after cardiac surgery. Phototesting indicated a normal erythematous response to 290- to 320-nm ultraviolet radiation, but she developed erythema from 6 joules/sq cm of 320- to 400-nm ...
Armstrong, R B, Leach, E E, Whitman, G, Harber, L C, Poh-Fitzpatrick M B, Olivotto I.   +5 more
openaire   +3 more sources

The Fever Tree: from Malaria to Neurological Diseases

Toxins, 2018
This article describes the discovery and use of the South American cinchona bark and its main therapeutic (and toxic) alkaloids, quinine and quinidine.
Sara Eyal
doaj   +1 more source

Quinidine-induced rise in ajmaline plasma concentration

, 1984
A high-performance liquid chromatographic method is described for the simultaneous determination of ajmaline and quinidine in human plasma. With 0·5 ml plasma samples of ajmaline and quinidine, concentrations as low as 0·001 and 0·01 μg ml−1 ...
Chuichi Kawai, Kazushi Yamada, Tsunetaro Sakurai, Katsuhiko Okumura, Masato Yasuhara, Ken-Ichi Inui, Ryohei Hori   +6 more
core   +1 more source