Results 31 to 40 of about 16,625 (226)

Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics

Frontiers in Veterinary Science
IntroductionQuinidine (QND) sulfate is an effective treatment for atrial fibrillation (AF) in horses, and several dosage regimens have been proposed to address its wide variability in response and potential adverse effects.
Taisuke Kuroda, Yohei Minamijima, Christopher Ken Kinman, Yuji Takahashi, Yusaku Ebisuda, Kaori Inoue, Hiroshi Ishikawa, Hiroshi Mita, Norihisa Tamura, Toshio Nukada, Pierre-Louis Toutain, Pierre-Louis Toutain, Minoru Ohta   +12 more
doaj   +1 more source

Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria

Pharmaceuticals, 2010
This review summarizes progress in treating severe and complicated malaria, which are global problems, claiming at least one million lives annually, and have been accompanied by advances in our understanding of the pathogenesis of severe malaria ...
Qigui Li, Peter Weina
doaj   +1 more source

Quinidine: an “Endangered Species” Drug Appropriate for Management of Electrical Storm in Brugada Syndrome

Indian Pacing and Electrophysiology Journal, 2013
Brugada syndrome is an inherited channelopathy associated with an increased risk of syncope and sudden cardiac death. In rare cases it can be manifested with electrical storm.
Stelios Paraskevaidis, MD, PhD, Efstratios K. Theofilogiannakos, MD, PhD, Vasileios Kamperidis, MD, Yiannis S. Chatzizisis, MD, PhD, Konstantinos Tsilonis, MD, Vassilios P. Vassilikos, MD, PhD, George Dakos, MD, PhD, George Stavropoulos, MD, Antonios Ziakas, MD, PhD, Stavros Hadjimiltiades, MD, PhD, Ioannis H. Styliadis, MD, PhD   +10 more
doaj   +1 more source

Exploring the Role of the KCNK1 Potassium Channel and Its Inhibition Using Quinidine in Treating Head and Neck Squamous Cell Carcinoma [PDF]

Clinical and Experimental Otorhinolaryngology
Objectives. Our study aimed to explore the role of the potassium channel KCNK1 in head and neck squamous cell carcinoma, focusing on its impact on tumor growth, invasion, and metastasis.
Hyun Woo Baek, Eunjung Han, Kyoung Ho Oh
doaj   +1 more source

Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. [PDF]

PLoS ONE, 2015
Intestinal circulatory disturbances, atony, edema and swelling are of great clinical relevance, but the related mechanisms and possible therapeutic options are poorly characterized, in part because of the difficulties to comprehensively analyze these ...
Ingmar Lautenschläger, Inéz Frerichs, Heike Dombrowsky, Jürgen Sarau, Torsten Goldmann, Karina Zitta, Martin Albrecht, Norbert Weiler, Stefan Uhlig   +8 more
doaj   +1 more source

Quinidine syncope in children

, 1987
Quinidine syncope and factors associated with it are well known among adult patients treated for cardiac arrhythmias. To define factors that may influence the occurrence of syncope in children taking quinidine, the clinical, anatomic ...
Dennis C. Crowley, Rocchini, Albert P., Dick, Macdonald, Crowley, Dennis C., Rebecca Snider, A., Webb, Catherine L., Robert L. Spicer, Robert H. Beekman, Beekman, Robert H., Rosenthal, Amnon, Macdonald Dick, Albert P. Rocchini, Amnon Rosenthal, Catherine L. Webb, A. Rebecca Snider, Spicer, Robert L.   +15 more
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Quinidine in falciparum malaria.

, 1981
Fourteen patients with falciparum malaria were successfully treated with oral quinidine. Twelve of these patients were followed for 35 days without recrudescence.
Chongsuphajaisiddhi, T, Bunnag, D, Looareesuwan, S, Harinasuta, T, White, NJ, White, Nicholas, Warrell, DA   +6 more
core   +1 more source

SPECTROPHOTOMETRIC DETERMINATION OF QUINIDINE SULFATE BY ION-PAIR FORMATION

Zagazig Journal of Pharmaceutical Sciences, 1997
A simple method for the determination of quinidine sulfate in tablets is based on the formation of an ion-pair between quinidine Comand thymol blue (TB) at pH=5.5 in aqueous-methanol solution.
Mamdouh Metwally
doaj   +1 more source

Physiologically‐based pharmacokinetic modeling of quinidine to establish a CYP3A4, P‐gp, and CYP2D6 drug–drug–gene interaction network

CPT: Pharmacometrics & Systems Pharmacology, 2023
The antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug–drug interaction (DDI) studies.
Denise Feick, Simeon Rüdesheim, Fatima Zahra Marok, Dominik Selzer, Helena Leonie Hanae Loer, Donato Teutonico, Sebastian Frechen, Maaike van derLee, Dirk Jan A. R. Moes, Jesse J. Swen, Matthias Schwab, Thorsten Lehr   +11 more
doaj   +1 more source

Low dose quinidine-mexiletine combination therapy versus quinidine monotherapy for treatment of ventricular arrhythmias

, 1990
Low dose quinidine-mexiletine combination therapy was compared with quinidine monotherapy in 15 patients with frequent ventricular premature complexes and nonsustained ventricular tachycardia in a dose escalation crossover study. Oral combination therapy
Wechsler, Mindy E., Giardina, Elsa-Grace V.   +1 more
core   +1 more source