Results 11 to 20 of about 16,625 (226)

Comparison between Inhibition of CatSper and KSper Channels with NNC 55-0396 and Quinidine on Human Sperm Function [PDF]

Iranian Journal of Medical Sciences
Background: Calcium enters human sperm through the “Cation Channel of Sperm” (CatSper), while potassium ions exit via the sperm potassium channel (KSper).
Ali Asghar Zarei, Sara Keshtgar, Masoud Haghani, Negar Firouzabadi, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +2 more sources

Efficacy of Anti-seizure Medications, Quinidine, and Ketogenic Diet Therapy for KCNT1-Related Epilepsy and Genotype-Efficacy Correlation Analysis

Frontiers in Neurology, 2022
AimTo evaluate the efficacy of anti-seizure medications (ASMs), quinidine, and ketogenic diet therapy (KDT) for KCNT1-related epilepsy and to explore genotype-efficacy correlations.MethodsWe collected the data for KCNT1-related epilepsy cases from our ...
Zehong Lin, Zehong Lin, Zehong Lin, Tian Sang, Tian Sang, Tian Sang, Ying Yang, Ying Yang, Ying Yang, Yuan Wu, Yuan Wu, Yuan Wu, Yan Dong, Taoyun Ji, Taoyun Ji, Taoyun Ji, Yuehua Zhang, Yuehua Zhang, Yuehua Zhang, Ye Wu, Ye Wu, Ye Wu, Kai Gao, Kai Gao, Kai Gao, Kai Gao, Yuwu Jiang, Yuwu Jiang, Yuwu Jiang, Yuwu Jiang, Yuwu Jiang   +30 more
doaj   +1 more source

Cardiocerebral channelopathy caused by KCND3 mutation in a child: A case report

Frontiers in Pediatrics, 2022
Early repolarization syndrome is rare in children. Mutation of genes encoding ion channels could display mixed electrophysiological phenotype of Kv4.3 including both cardiac phenotype (early repolarization syndrome, atrial fibrillation) and cerebral ...
Yi Zhang, He Jiang, Xiao-mei Li
doaj   +1 more source

A case report of pitfall of fever and altered mental status: cerebral malaria due to in an adult traveler returning from Congo [PDF]

Journal of Neurocritical Care, 2023
Background Cerebral malaria, caused by Plasmodium falciparum, can lead to severe neurological complications. It is more frequently observed in children than in adults.
Soo-Hyun Park, Yerim Kim, Yeo Jin Kim, Jong Seok Bae, Ju-Hun Lee   +4 more
doaj   +1 more source

Case Report of Novel Genetic Variant in KCNT1 Channel and Pharmacological Treatment With Quinidine. Precision Medicine in Refractory Epilepsy

Frontiers in Pharmacology, 2021
Case introduction: In this work we present a female infant patient with epilepsy of infancy with migrating focal seizures (EIMFS). Although many pharmacological schemes were attempted, she developed an encephalopathy with poor response to antiepileptic ...
M. C. Kravetz, M. S. Viola, J. Prenz, M. Curi, G. F. Bramuglia, G. F. Bramuglia, S. Tenembaum   +6 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

Frontiers in Pharmacology, 2021
Aims: The short QT syndrome type 1 (SQT1) is linked to hERG channel mutations (e.g., N588K). Drug effects on hERG channel gating kinetics in SQT1-cells have not been investigated.Methods: This study used hiPSC-CMs of a healthy donor and a SQT1-patient ...
Mengying Huang, Zhenxing Liao, Zhenxing Liao, Xin Li, Xin Li, Zhen Yang, Zhen Yang, Xuehui Fan, Xuehui Fan, Yingrui Li, Zhihan Zhao, Siegfried Lang, Siegfried Lang, Lukas Cyganek, Lukas Cyganek, Xiaobo Zhou, Xiaobo Zhou, Xiaobo Zhou, Ibrahim Akin, Ibrahim Akin, Martin Borggrefe, Martin Borggrefe, Ibrahim El-Battrawy, Ibrahim El-Battrawy   +23 more
doaj   +1 more source

Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine

Neurobiology of Disease, 2000
Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is characterized mainly by schwannomas, as well as menigiomas and gliomas. The NF2 gene product merlin/schwannomin acts as a tumor suppressor. Schwann cells derived from NF2 schwannomas
C. Rosenbaum, M. Kamleiter, P. Grafe, L. Kluwe, V.-F. Mautner, H.W. Müller, C.O. Hanemann   +6 more
doaj   +1 more source

Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model

Frontiers in Pharmacology, 2019
The cardiac Nav1.5 mediated sodium current (INa) generates the upstroke of the action potential in atrial and ventricular myocytes. Drugs that modulate this current can therefore be antiarrhythmic or proarrhythmic, which requires preclinical evaluation ...
Dieter V. Van de Sande, Ivan Kopljar, Ivan Kopljar, Ard Teisman, David J. Gallacher, Dirk J. Snyders, Hua Rong Lu, Alain J. Labro   +7 more
doaj   +1 more source